basic FUNCTION
| essential for the survival of splenic precursors during organogenesis |
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involved in transcriptional deregulation of G1/S growth-control genes, mediated in large part through blockade of PP1/PP2A phosphatase activity |
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TLX1-mediated differentiation arrest may be achieved in part through a mechanism that involves redirection of CREBBP and/or its sequestration in repressive chromatin domains |
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NK-like homeodomain transcription factor that is both normally required for embryonic development and aberrantly expressed in T-cell acute lymphoblastic leukemia |
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having a dual function regulator whose activity in respect to FHL1 is critically dependent upon its cellular concentration, as well as cell type and promoter context |
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homeodomain transcription factor involved in splenogenesis and neuron formation |
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TLX1-mediated target gene activation can occur in part via derepression strategies involving Gro/TLE corepressors |
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directly downregulates the expression of CHEK1 and additional mitotic control genes and induces loss of the mitotic checkpoint in nontransformed preleukemic thymocytes |