Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TLX1 contributors: mct - updated : 10-11-2010
HGNC name T-cell leukemia homeobox 1
HGNC id 5056
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
  • an Eh1-like motif, essential for optimal transcriptional activation of two TLX1 target genes, ALDH1A1 and FHL1
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • essential for the survival of splenic precursors during organogenesis
  • involved in transcriptional deregulation of G1/S growth-control genes, mediated in large part through blockade of PP1/PP2A phosphatase activity
  • TLX1-mediated differentiation arrest may be achieved in part through a mechanism that involves redirection of CREBBP and/or its sequestration in repressive chromatin domains
  • NK-like homeodomain transcription factor that is both normally required for embryonic development and aberrantly expressed in T-cell acute lymphoblastic leukemia
  • having a dual function regulator whose activity in respect to FHL1 is critically dependent upon its cellular concentration, as well as cell type and promoter context
  • homeodomain transcription factor involved in splenogenesis and neuron formation
  • TLX1-mediated target gene activation can occur in part via derepression strategies involving Gro/TLE corepressors
  • directly downregulates the expression of CHEK1 and additional mitotic control genes and induces loss of the mitotic checkpoint in nontransformed preleukemic thymocytes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the ubiquitous transcription factor CTF1 and PBX homeodomains proteins
  • interaction with SMARCD3, NR4A3, NFKB2
  • can regulate target genes including ALDH1A1 and FHL1
  • interacts with TLE1 via an Eh1-like motif
  • interacting with SIX2, HOXA2 (loss-of-function of TLX1 leads to loss of SIX2 expression and loss-of-function of HOXA2 leads to expanded SIX2 expression)
  • TLX1 and NOTCH1 synergistically regulate transcription in T-ALL, at least in part via the sharing of a TLE corepressor and by augmenting expression of MYC
  • co-operation between TLX1 and MEIS1, MEIS2 proteins may have a significant role in T-cell leukemogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TCL3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    and fused with TCRD in acute lymphoblastic leukemia
    tumoral       gain of function
    in T-acute lymphoblastic leukemia with t(10;14) (q24;q11), or t(7;10) (q35;q24), or t(5;14) (q35;q32)
    tumoral     --over  
    in acute lymphoblastic leukemia with good outlook
    tumoral     --other  
    inappropriately expressed in a major subgroup of T cell acute lymphoblastic leukemia (T-ALL) where it is strongly associated with activating NOTCH1 mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS