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FLASH GENE

Symbol

TLN2

contributors: mct - updated : 10-06-2015

HGNC name	talin 2
HGNC id	15447

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q22.2      Physical location : 62.939.509 - 63.136.827
Synonym symbol(s)	KIAA0320, ILWEQ, DKFZp451B1011, DKFZp686I0976, DKFZp686K0979

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	454.06 kb     57 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015059 57 - 11650 NP_055874 - 2542 - Olsen (2006) TLN2t - - - - - - 2009 19220457 truncated isoform short testis-specific talin 2 isoform in elongating spermatids

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Homo sapiens Adult   heart       highly Homo sapiens Fetal Nervous brain       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac   highly Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three actin-binding sites (ABS1-3): one in the N-terminal head, and two in the C-terminal rod domain
	a FERM domain, with 3 subdomains (F1, F2, F3) functioning as a linker between PIPkin or integrins and F-actin at sites of cell-matrix adhesions
	F2 and F3 FERM subdomains contribute to binding, and EGFP-tagged FERM subdomains colocalize with actin stress fibers
	a I/LWEQ domain

HOMOLOGY

interspecies

homolog to murine Talin

Homologene

FAMILY

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytoskeleton
text	actin cytoskeleton, synapses
	localizes to costameres and intercalated disks
	observed in both focal and fibrillar adhesions

basic FUNCTION	cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts
	may be involved in connections of major cytoskeletal structures to the plasma membrane
	link the actin cytoskeleton to the extracellular environment through interactions with beta-integrins and actin
	serves as an essential link between integrins and the actin cytoskeleton in several similar, but functionally distinct, adhesion complexes, including focal adhesions, costameres, and intercalated disks
	may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated muscle
	TLN1, TLN2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions (MTJs)
	plays an important role in cell adhesion and recycling of synaptic vesicles
	adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin
	TLN1 and TLN2 have distinct functions in the myocardium

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds with high affinity to vinculin and with low affinity to integrins
	interacts with PIP5K1C
	DSP and TLN2 mRNAs associate with FXR1 in a complex

cell & other

REGULATION

activated by

during muscle differentiation at both the mRNA and protein levels

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS