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FLASH GENE
Symbol TLN2 contributors: mct - updated : 10-06-2015
HGNC name talin 2
HGNC id 15447
Location 15q22.2      Physical location : 62.939.509 - 63.136.827
Synonym symbol(s) KIAA0320, ILWEQ, DKFZp451B1011, DKFZp686I0976, DKFZp686K0979
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 454.06 kb     57 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ANXA2 15q21-q22 annexin A2 NARG2 15q21.3 NMDA receptor-regulated gene 2 RORA 15q21-q22 RAR-related orphan receptor A HCP38 15q21.3 cytochrome c, somatic pseudogene LOC390590 15 similar to RAR-related orphan receptor A isoform a; RAR-related orphan receptor alpha; retinoic acid receptor-related orphan receptor alpha; transcription factor RZR-alpha; ROR-alpha FLJ20136 LOC145741 15q21.3 hypothetical LOC145741 LOC390591 15 similar to nucleophosmin LOC388125 15 similar to hypothetical LOC237397 FLJ38723 15q21.3 hypothetical protein FLJ38723 TLN2 15q15-q21 talin 2 LOC390592 15 similar to TSH receptor suppressor element-binding protein-1; TSEP-1 TPM1 15q22.1 tropomyosin 1 (alpha) LACTB 15q22.1 lactamase, beta RPS27L 15q21.3 ribosomal protein S27-like LOC51762 PSFL 15q22.1 anterior pharynx defective 1B-like LOC388126 15 LOC388126 FLJ20151 15q22.1 hypothetical protein FLJ20151 CA12 15q22 carbonic anhydrase XII USP3 15q22.3 ubiquitin specific protease 3 LOC390593 15 similar to RIKEN cDNA 1110004B15 HERC1 15q22 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 DAPK2 15q22.1 death-associated protein kinase 2 FLJ22875 15q22.1 hypothetical protein FLJ22875 SNX1 15q22-q23 sorting nexin 1 SNX22 20q12-13.1 sorting nexin 22 PPIB 15q21-q22 peptidylprolyl isomerase B (cyclophilin B) CSNK1G1 15q22.1-q22.31 casein kinase 1, gamma 1 KIAA0101 15q22.1 casein kinase 1, gamma 1 TRIP4 15q22.1 thyroid hormone receptor interactor 4 KIAA0295 15q21.3-q22.1 thyroid hormone receptor interactor 4 OAZ2 15q22 ornithine decarboxylase antizyme 2 RBPMS2 15q22.1 RNA-binding protein with multiple splicing 2 FLJ22692 15q22.1 hypothetical protein FLJ22692 pp9099 15q22.1 PH domain-containing protein LOC348094 15q22.2 hypothetical protein LOC348094 ACP33 15q21-q22 hypothetical protein LOC348094
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
57 - 11650 - 2542 - Olsen (2006)
- - - - - - 2009 19220457
  • truncated isoform
  • short testis-specific talin 2 isoform in elongating spermatids
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiensAdult
     heart   highly Homo sapiensFetal
    Nervousbrain   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac highly Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three actin-binding sites (ABS1-3): one in the N-terminal head, and two in the C-terminal rod domain
  • a FERM domain, with 3 subdomains (F1, F2, F3) functioning as a linker between PIPkin or integrins and F-actin at sites of cell-matrix adhesions
  • F2 and F3 FERM subdomains contribute to binding, and EGFP-tagged FERM subdomains colocalize with actin stress fibers
  • a I/LWEQ domain
  • HOMOLOGY
    interspecies homolog to murine Talin
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • actin cytoskeleton, synapses
  • localizes to costameres and intercalated disks
  • observed in both focal and fibrillar adhesions
  • basic FUNCTION
  • cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts
  • may be involved in connections of major cytoskeletal structures to the plasma membrane
  • link the actin cytoskeleton to the extracellular environment through interactions with beta-integrins and actin
  • serves as an essential link between integrins and the actin cytoskeleton in several similar, but functionally distinct, adhesion complexes, including focal adhesions, costameres, and intercalated disks
  • may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated muscle
  • TLN1, TLN2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions (MTJs)
  • plays an important role in cell adhesion and recycling of synaptic vesicles
  • adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin
  • TLN1 and TLN2 have distinct functions in the myocardium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds with high affinity to vinculin and with low affinity to integrins
  • interacts with PIP5K1C
  • DSP and TLN2 mRNAs associate with FXR1 in a complex
  • cell & other
    REGULATION
    activated by during muscle differentiation at both the mRNA and protein levels
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS