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FLASH GENE
Symbol TLN2 contributors: mct - updated : 10-06-2015
HGNC name talin 2
HGNC id 15447
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
57 - 11650 - 2542 - Olsen (2006)
- - - - - - 2009 19220457
  • truncated isoform
  • short testis-specific talin 2 isoform in elongating spermatids
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiensAdult
     heart   highly Homo sapiensFetal
    Nervousbrain   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac highly Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three actin-binding sites (ABS1-3): one in the N-terminal head, and two in the C-terminal rod domain
  • a FERM domain, with 3 subdomains (F1, F2, F3) functioning as a linker between PIPkin or integrins and F-actin at sites of cell-matrix adhesions
  • F2 and F3 FERM subdomains contribute to binding, and EGFP-tagged FERM subdomains colocalize with actin stress fibers
  • a I/LWEQ domain
  • HOMOLOGY
    interspecies homolog to murine Talin
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • actin cytoskeleton, synapses
  • localizes to costameres and intercalated disks
  • observed in both focal and fibrillar adhesions
  • basic FUNCTION
  • cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts
  • may be involved in connections of major cytoskeletal structures to the plasma membrane
  • link the actin cytoskeleton to the extracellular environment through interactions with beta-integrins and actin
  • serves as an essential link between integrins and the actin cytoskeleton in several similar, but functionally distinct, adhesion complexes, including focal adhesions, costameres, and intercalated disks
  • may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated muscle
  • TLN1, TLN2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions (MTJs)
  • plays an important role in cell adhesion and recycling of synaptic vesicles
  • adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin
  • TLN1 and TLN2 have distinct functions in the myocardium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds with high affinity to vinculin and with low affinity to integrins
  • interacts with PIP5K1C
  • DSP and TLN2 mRNAs associate with FXR1 in a complex
  • cell & other
    REGULATION
    activated by during muscle differentiation at both the mRNA and protein levels
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS