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FLASH GENE
Symbol TLE3 contributors: npt/SGE - updated : 27-07-2010
HGNC name transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
HGNC id 11839
Location 15q23      Physical location : 70.340.542 - 70.390.256
Synonym name
  • enhancer of split groucho 3
  • enhancer of split groucho-like protein 3
  • transducin-like enhancer protein 3
  • Synonym symbol(s) ESG3, ESG, KIAA1547, HsT18976, GRG3, FLJ39460
    DNA
    TYPE functioning gene
    STRUCTURE 46.00 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PIAS1 15q21.3-q22.1 protein inhibitor of activated STAT, 1 MGC4809 15q22.2 serologically defined breast cancer antigen NY-BR-20 CLN6 15q23 ceroid-lipofuscinosis, neuronal 6, late infantile, variant FEM1B 15q22 fem-1 homolog b (C. elegans) ITGA11 15q22.3-q23 integrin, alpha 11 CORO2B 15q22-q23 coronin, actin binding protein, 2B ANP32A 15q22-q23 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A FLJ11722 15q22.31 hypothetical protein FLJ11722 LOC390600 15 similar to RIKEN cDNA 2810413N20 NOX5 15q22.31 NADPH oxidase, EF hand calcium-binding domain 5 SPESP1 15q22.31 sperm equatorial segment protein 1 FLJ33768 15q22.31 hypothetical protein FLJ33768 GLCE 15q22.31 glucuronyl C5-epimerase MPRG 15q22.31 glucuronyl C5-epimerase KIF23 15q22-q23 kinesin family member 23 RPLP1 15q22 ribosomal protein, large, P1 LOC388130 15 LOC388130 LOC388131 15 LOC388131 TLE3 15q22 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) UACA 15q22-q24 uveal autoantigen with coiled-coil domains and ankyrin repeats LOC123397 15q22.32 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) FLJ11196 15q22.32 acheron LOC390601 15 similar to keratin 8, type II cytoskeletal - human THAP10 15q22.32 THAP domain containing 10 FLJ20156 15q22.32 hypothetical protein FLJ20156 LOC283675 15q22.32 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC196993 15q22.32 hypothetical protein LOC196993 LOC390602 15 similar to High mobility group protein 1 (HMG-1) (Amphoterin) (Heparin-binding protein p30) LOC196994 15q22.32 similar to hypothetical protein LOC388132 15 similar to 60S ribosomal protein L17 (L23) FLJ13710 15q22.33 hypothetical protein FLJ13710 NR2E3 15q24 nuclear receptor subfamily 2, group E, member 3 MYO9A 15q22-q23 myosin IXA
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 5345 - 769 - Miyasaka (1993)
    20 - 5318 - 760 - Miyasaka (1993)
    20 - 5354 - 772 - Miyasaka (1993)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivefemale systemplacenta   
    Respiratorylung    
     respiratory tractlarynx   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • casein kinase II site/nuclear localization sequence motif
  • a pleckstrin homology (PH) domain
  • seven WD repeats (Trp-Asp domains)
  • conjugated PhosphoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila split Groucho (Notch signaling pathway)
    homolog to murine Tle3 (98.8pc)
    homolog to rattus Tle3 (99.2pc)
    Homologene
    FAMILY
  • WD repeat Groucho/TLE family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional corepressor binding to a number of transcription factors
  • inhibiting the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling
  • might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (Carvalho 2010)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed with NOTCH implicating these molecules in the maintenance of the undifferentiated state in epithelial cells
  • interacting with AES and TCF4 to influencing pituitary growth and development
  • binding LEF1, TCF7, TCF7L1 and TCF7L2, FOXA2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    up-regulated (6- to 17-fold) in prostate tumors (Nakaya 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS