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FLASH GENE
Symbol TLE3 contributors: npt/SGE - updated : 27-07-2010
HGNC name transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
HGNC id 11839
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivefemale systemplacenta   
Respiratorylung    
 respiratory tractlarynx   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • casein kinase II site/nuclear localization sequence motif
  • a pleckstrin homology (PH) domain
  • seven WD repeats (Trp-Asp domains)
  • conjugated PhosphoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila split Groucho (Notch signaling pathway)
    homolog to murine Tle3 (98.8pc)
    homolog to rattus Tle3 (99.2pc)
    Homologene
    FAMILY
  • WD repeat Groucho/TLE family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional corepressor binding to a number of transcription factors
  • inhibiting the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling
  • might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (Carvalho 2010)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed with NOTCH implicating these molecules in the maintenance of the undifferentiated state in epithelial cells
  • interacting with AES and TCF4 to influencing pituitary growth and development
  • binding LEF1, TCF7, TCF7L1 and TCF7L2, FOXA2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    up-regulated (6- to 17-fold) in prostate tumors (Nakaya 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS