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FLASH GENE
Symbol THBS4 contributors: mct - updated : 08-07-2011
HGNC name thrombospondin 4
HGNC id 11788
Location 5q14.1      Physical location : 79.331.169 - 79.379.105
Synonym symbol(s) TSP4
DNA
TYPE functioning gene
STRUCTURE 47.94 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
text structure calcium and heparin binding sites
MAPPING cloned Y linked   status provisional
Map cen - D5S1977 - D5S1962 - ARSB - THBS4 - D5S620 - D5S2029 - D5S627 - D5S626 - HAPLN1 - D5S469 - D5S428 - qter
Authors GeneMap
Physical map
SCAMP1 5q13.3-q14.1 secretory carrier membrane protein 1 LHFPL2 5q13.3 lipoma HMGIC fusion partner-like 2 ARSB 5q13 arylsulfatase B DMGDH 5q12.2-q12.3 arylsulfatase B BHMT2 5q13 betaine-homocysteine methyltransferase 2 BHMT 5q13.1-q15 betaine-homocysteine methyltransferase JMY 5q14.1 junction-mediating and regulatory protein HOMER1 5q25 homer homolog 1 (Drosophila) LOC133748 5q14.1 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) FLJ38499 5q14.1 hypothetical protein FLJ38499 CMYA5 5q14.1 cardiomyopathy associated 5 LOC391802 5 similar to 60S ribosomal protein L10 (QM protein homolog) LOC345778 5q14.1 similar to hypothetical protein THBS4 5q13 thrombospondin 4 C5orf12 5 chromosome 5 open reading frame 12 LOC391803 5 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC134478 5q14.1 similar to cytoplasmic beta-actin NYD-TSP1 5q14.1 testis-specific protein NYD-TSP1 LOC391804 5 similar to hypothetical protein LOC391805 5 hypothetical gene supported by NM_004269 LOC153817 5q14.1 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) ZFYVE16 5p15.2-q14.3 zinc finger, FYVE domain containing 16 LOC167555 5q14.1 similar to AASA9217 LOC340120 5q14.1 similar to RIKEN cDNA 6430502M16 gene LOC389306 5 LOC389306 DBIL1 5pter-p15.32 diazepam binding inhibitor-like 1 DHFR 5q13.2 dihydrofolate reductase MSH3 5q11-q12 mutS homolog 3 (E. coli) RASGRF2 5q13 Ras protein-specific guanine nucleotide-releasing factor 2 CKMT2 5q13.3 creatine kinase, mitochondrial 2 (sarcomeric) DKFZp761J139 5q14.1 hypothetical protein DKFZp761J139 CACH-1 5q14.1 cytosolic acetyl-CoA hydrolase SSBP2 5q14.1 single-stranded DNA binding protein 2 DSS1P1 5q14 single-stranded DNA binding protein 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 3233 - 961 - 1999 10501972
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartvalve    Homo sapiens
Nervousbrainforebraincerebral cortex highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
polypeptide lacking the procollagen homology domain and type I repeats (TSP) of THBS1,with type II (EGF-like) and seven type III (Ca++ binding) repeats
mono polymer homomer , trimer
HOMOLOGY
interspecies homolog to murine Thbs4
Homologene
FAMILY
  • thrombospondin family
  • extracellular calcium-binding protein family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    text basement membrane
    basic FUNCTION
  • mediating cell to cell and cell to matrix interactions
  • extracellular-matrix glycoproteins implicated in the control of synaptogenesis and neurite growth
  • involved in cell adhesion and migration
  • important role for this matricellular protein in the local regulation of inflammation associated with atherogenesis
  • highly conserved matricellular protein regulating inflammation, angiogenesis and extracellular matrix remodeling
  • myocyte-interstitial mechano-signaling molecule central to adaptive cardiac contractile responses to acute stress, which appears to play a crucial role in the transition to chronic cardiac dilatation and failure
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component homotrimer disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by increased methylation in colorectal cancer (
    Susceptibility myocardial infarction
    Variant & Polymorphism SNP A387P significantly associated to myocardial infarction
    Candidate gene
    Marker
  • its level may be a biomarker for the occurrence of colorectal adenomas and carcinoma
  • powerful marker for diffuse-type gastric adenocarcinomas and to provide an initial characterization of its expression in the course of this disease
  • may be an endothelial specific marker of cardiac overload
  • Therapy target
    ANIMAL & CELL MODELS
  • in mice lacking TSP4 (Tsp4&
  • 8315;-/-), hearts failed to acutely augment contractility or activate stretch-response pathways (ERK1/2 and Akt) on exposure to acute pressure overload