| basic FUNCTION
| mediating cell to cell and cell to matrix interactions |
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extracellular-matrix glycoproteins implicated in the control of synaptogenesis and neurite growth  |
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involved in cell adhesion and migration |
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important role for this matricellular protein in the local regulation of inflammation associated with atherogenesis |
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highly conserved matricellular protein regulating inflammation, angiogenesis and extracellular matrix remodeling |
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is involved in regulating the adaptive responses of the heart to pressure overload, suggesting its important role in myocardial remodeling |
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myocyte-interstitial mechano-signaling molecule central to adaptive cardiac contractile responses to acute stress, which appears to play a crucial role in the transition to chronic cardiac dilatation and failure |
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injury-induced spinal TSP4 may contribute to spinal presynaptic hypersensitivity and neuropathic pain states |
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THBS4 expression in breast cancer-associated extracellular matrix contributes to the activated stromal response exhibited during tumour progression and this may facilitate invasion of tumour cells |
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functions as an extracellular matrix (ECM) scaffold at myotendinous junctions (MTJs), with potential therapeutic uses in tendon strengthening and repair |
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possess proangiogenic activity |
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THBS4 regulates skeletal muscle integrity |
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functions in cardiovascular and nervous systems, inflammation, cancer, and the motor unit, which have attracted attention to this extracellular matrix (ECM) protein |
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appears to have some structural functions in ECM |
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is protective in cardiac and skeletal muscle, where it activates an adaptive endoplasmic reticulum (ER) stress response, induces expansion of the ER, and enhances sarcolemmal stability |
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is an important protein in the development of cardiac hypertrophy and aortic dissections in ANGPT2-induced hypertension |
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expression in macrophages increases their accumulation in tissues during the acute inflammatory process |
