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FLASH GENE
Symbol TES contributors: mct/npt/pgu - updated : 29-06-2012
HGNC name testis derived transcript (3 LIM domains)
HGNC id 14620
Location 7q31.2      Physical location : 115.850.580 - 115.898.835
Synonym name testin
Synonym symbol(s) TESS2, DKFZP586B2022, TESTIN, MGC1146, TESS
DNA
TYPE functioning gene
STRUCTURE 48.30 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure 1a/7 to 7, two Cpg islands
MAPPING cloned Y linked N status provisional
Map cen - [D7S486 - TES - D7S522 ] - HERVH2 - CAV2 - CAV1 - MET - D7S2460 -CAPZA2 - qter
Text [fra7G ]
Physical map
IMMP2L 7q31 IMP2 inner mitochondrial membrane protease-like (S. cerevisiae) LRRN3 7q21.12 leucine rich repeat neuronal 3 LOC392092 7 similar to Argininosuccinate synthase (Citrulline--aspartate ligase) DOCK4 7q21.13-q31.1 similar to Argininosuccinate synthase (Citrulline--aspartate ligase) ZNF277 7q31.1 zinc finger protein (C2H2 type) 277 IFRD1 7q31 interferon-related developmental regulator 1 FLJ39575 7q31.1 hypothetical protein FLJ39575 NPM1P14 7q31.1 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 14 FLJ13576 7q31.32 hypothetical protein FLJ13576 FLJ31818 7q31.1 hypothetical protein FLJ31818 GPR85 7q31 G protein-coupled receptor 85 LOC389548 7 hypothetical gene supported by BX537645 PPP1R3A 7q11.23 protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle) FOXP2 7q31 forkhead box P2 HIC 7q31.1 forkhead box P2 TFEC 7q31.2 transcription factor EC TES 7q31.2 testis derived transcript (3 LIM domains) CAV2 7q31.1-q31.2 caveolin 2 CAV1 7q31.2-q31.3 caveolin 1, caveolae protein, 22kDa MET 7q31.2-q31.3 met proto-oncogene (hepatocyte growth factor receptor) CAPZA2 7q31.2-q31.3 capping protein (actin filament) muscle Z-line, alpha 2 ST7 7q31.1-q31.3 suppression of tumorigenicity 7 WNT2 7q31 wingless-type MMTV integration site family member 2 GASZ 7q31.31 GASZ CFTR 7q31.3 cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) CORTBP2 7q31.3 cortactin binding protein 2 LSM8 7q31.1-q31.3 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) ANKRD7 7q31 ankyrin repeat domain 7 KCND2 7q31-q32 potassium voltage-gated channel, Shal-related subfamily, member 2 TM4SF12 7 transmembrane 4 superfamily member 12 ING3 7q31 inhibitor of growth family, member 3 FLJ21986 7q31.32 hypothetical protein FLJ21986 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C HCP19 7q31.32 cytochrome c, somatic pseudogene LOC136143 7q31.32 similar to ribosomal protein L18; 60S ribosomal protein L18 PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 AASS 7q31.3 aminoadipate-semialdehyde synthase
RNA
TRANSCRIPTS type messenger
text three isoforms 1 and 2 from 3'utr region, 1, 2 vs 3 by alternative splice of exon 1a, (1,2), 1b (3)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 2799 48 421 - 2000 10950921
7 splicing 2633 47 412 - 2000 10950921
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage lymphoblastoid cells
cell lines cancer cell lines but not in hematological malignancies cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PET domain in the N-terminus
  • four phosphorylation sites
  • one glycosylation site
  • one cytochrome C heme binding site
  • three cysteine-rich LIM/double zinc finger motifs (LIM domains) at the C terminus (LIM3 domain lacking the FPPPP motif, binds to the EVH1 domain of ENAH, but not to those of VASP or EVL)(Boeda 2007)
  • HOMOLOGY
    interspecies homolog to murine Testin
    intraspecies homolog to SOX9
    Homologene
    FAMILY
  • prickle/espinas/testin family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • putative tumor suppressor and localizes to the cytoplasm as a component of focal adhesions and cell contacts
  • basic FUNCTION
  • transcriptional regulation through protein-protein interactions
  • actin-binding protein mainly located at focal adhesions (Rotter 2005)
  • atypical EVH1 binding partner and regulator specific to a single ENAH/VASP family member (Boeda 2008)
  • plays a role in cell spreading and motility as well as cytoskeletal organisation, e.g. actin stress fibre assembly
  • has different conformational states in different cellular compartments, and a "closed" conformational state of TES may be involved in nucleolar localization (
  • novel protein partner of the CASR that regulates receptor-mediated Rho signalling, and supports CASR-dependent activation of Rho kinase
  • involved in endothelial cell (EC) functions relevant to atherosclerosis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific ENAH interacting partner
  • interaction between TES and spectrin is mediated by a LIM (Lin-11, Isl-1 and Mec3) domain of TES and by the alpha10 repeat of alphaII-spectrin (Rotter 2005)
  • interaction between TES and EVL (co-localization of these two proteins at focal adhesions) (Rotter 2005)
  • SRY and NR5A1 co-operate to activate the human SOX9 homologous TES, a process dependent on phosphorylated NR5A1
  • SOX9 activates TES, augmented by NR5A1, suggesting a mechanism for maintenance of SOX9 expression by auto-regulation
  • interplay between the CASR and testin in the regulation of CASR-mediated Rho signalling with possible effects on the cytoskeleton
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by hypermethylation in ovarian carcinoma
    tumoral   amplification    
    with MET oncogene in gastric cancer
    constitutional     --low  
    association between reduced TES expression and coronary artery disease
    tumoral   LOH    
    in primary gastric cancer
    tumoral     --low  
    is the most frequently methylated and silenced gene yet reported in childhood acute lymphoblastic leukaemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene best candidate tumor suppressor gene at 7q31
    Marker
    Therapy target
    ANIMAL & CELL MODELS