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FLASH GENE
Symbol TES contributors: mct/npt/pgu - updated : 29-06-2012
HGNC name testis derived transcript (3 LIM domains)
HGNC id 14620
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
by hypermethylation in ovarian carcinoma
tumoral   amplification    
with MET oncogene in gastric cancer
constitutional     --low  
association between reduced TES expression and coronary artery disease
tumoral   LOH    
in primary gastric cancer
tumoral     --low  
is the most frequently methylated and silenced gene yet reported in childhood acute lymphoblastic leukaemia
Susceptibility
Variant & Polymorphism
Candidate gene best candidate tumor suppressor gene at 7q31
Marker
Therapy target
ANIMAL & CELL MODELS