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FLASH GENE
Symbol TCP1 contributors: mct/npt/pgu - updated : 27-09-2015
HGNC name t-complex 1
HGNC id 11655
Location 6q25.3      Physical location : 160.199.530 - 160.210.735
Synonym name
  • TF55/TCP-1
  • T-complex protein 1, alpha subunit
  • tailless complex polypeptide 1
  • Chaperonin Containing Tcp1
    • Synonym symbol(s) CCT1, D65230E, CCT-alpha, CCTa, TCP-1-alpha, TRIC, CCT
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text overlapping in opposite sense in the 3' region of ACAT2
    STRUCTURE 11.21 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see TCP10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2463 - 556 - 2007 17939680
    11 - 2377 - 401 - 2007 17939680
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer
    HOMOLOGY
    interspecies homolog to murine Tcp1
    Homologene
    FAMILY
  • TCP-1 chaperonin family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • potential chaperonin
  • modulating TP53-dependent function and avoid senescence
  • maintains cellular protein folding homeostasis in the eukaryotic cytosol by assisting the biogenesis of many proteins, including actins, tubulins, and regulators of the cell cycle
  • required for maturation of sphingosine kinase 1
  • folds the cytoskeletal protein actin
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin
  • multi-subunit molecular machine thought to assist in the folding of 10p100 of newly translated cytosolic proteins in eukaryotes (
  • normal TCP1 function is ultimately required for the morphogenesis and survival of sensory neurons of the retina, and suggest the chaperonin TCP1 deficiency as a potential, yet unexplored, cause of neurodegenerative diseases
  • TCP1 complex harbor at least one putative zona pellucida binding protein, ZPBP2, playing a role in the mediation of sperm-zona pellucida interaction
  • molecular chaperone TRiC/CCT is essential for correct protein folding, DYRK1A binding, and nuclear accumulation of DCAF7
    • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex, 97kDa, containing
  • several structurally related subunits, assembled into a TCP1 ring and mediating ATP dependent, monomeric protein folding
  • part of chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC)
  • molecular chaperones having a post-translational role in maintaining the native form of actin during its slow transport to the axon terminal and ensuring its correct assembly into microfilaments
  • complex formed by two back-to-back stacked hetero-octameric rings that assists the folding of actins, tubulins, and other proteins in an ATP-dependent manner
    • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • PDCL is thought to act as a TCP1 co-factor
    • protein
  • interacting with PLK1 (is required for the biogenesis of functional PLK1)
  • PDCL2 physically interacts with TCP1 and modulates its folding activity
  • formation of a stable complex between chaperonin-containing TCP1 and HSPA8, two eukaryotic representatives of these chaperone families
  • interacts with huntingtin and results in decrease of aggregate formation followed by increase of cell survival
  • TCP1 ring complex/chaperonin-containing TCP1 (TRiC/CCT) were identified as major DCAF7-binding proteins, and phosphorylation sites in both DCAF7 and TRiC/CCT were identified
  • key checkpoint function for the chaperonin TCP1, which specifically associates with nascent TAF5 for subsequent handover to TAF6-TAF9 and ultimate holo-TBP formation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colon carcinomas
    Susceptibility to Alzheimer disease (AD)
    Variant & Polymorphism other variant increasing risk of AD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS