SUBCELLULAR LOCALIZATION
| plasma membrane,junction,tight
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| plasma membrane,junction,adherens
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| text
| at the centrosome, TBCD is required for initiation of microtubule growth and organization of the mitotic spindle |
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both ARL2 and TBCD also localize to centrosomes  |
| basic FUNCTION
| modulator of microtubule dynamic by sequestering beta tubulin GTP bound heterodimers |
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involved in the pathway leading to correctly folded beta-tubulin from folding intermediates |
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with ARL2 participate in apical junctional complex disassembly and epithelial depolarization |
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playing a role D at centrosomes that is important to its function in polymerization of tubulin and organization of the mitotic spindle |
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plays a role in cells independent of its presumed role in folding tubulin heterodimers (pMID: 17704193) |
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ARL2 and TBCD participate in apical junctional complex (AJC), disassembly and epithelial depolarization |
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TBCD and TBCE are also capable of acting in a reverse reaction in which they disrupt native heterodimers |
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inability of TBCD to disrupt microtubule integrity upon overexpression can be overcome by siRNA-mediated suppression of expression of the TBCD regulator ARL2 (ADP ribosylation factor-like protein) |
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ARL2, and its cytosolic binding partner cofactor D (TBCD), is important in tubulin folding and microtubule dynamics |
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participate in centriolar and ciliary basal body assembly, strongly suggesting a more wider role in processes linked to microtubule nucleation |
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is a novel functional contributor to mammalian cerebral cortex development, |
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is also required for axon and dendrite maintenance in olfactory projection neurons (PNs) |
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co-chaperones required for assembly and disassembly of the alpha/beta-tubulin heterodimer, the structural unit of microtubules |
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role of TBCD in modulating stability and polymerization of microtubules |
