Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TBC1D7 | contributors: npt/mct - updated : 09-04-2014 |
HGNC name | TBC1 domain family, member 7 |
HGNC id | 21066 |
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Corresponding disease |
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Location | 6p24.1 Physical location : 13.305.185 - 13.328.787 | ||
Synonym name | cell migration-inducing protein 23 | ||
Synonym symbol(s) | dJ257A7.3, FLJ32666, DKFZp686N2317, PIG51, TBC7 |
DNA |
TYPE | functioning gene |
STRUCTURE | 23.53 kb 8 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
| umbilical cord blood | |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to murine 2610009C09Rik |
homolog to rattus LOC361227 |
Homologene |
FAMILY |
CATEGORY | regulatory |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytosolic,vesicle |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | TSC1-TSC2-TBC1D7 complex , TSC1-TSC2-TBC1D7 (TSC-TBC) complex is the functional complex that senses specific cellular growth conditions and possesses Rheb-GAP activity |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
|
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | MGCPH |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
| Selective suppression of TBC1D7 and/or inhibition of the TBC1D7-TSC1 complex formation could be promising therapeutic strategies for lung cancer therapy (Sato 2010) |
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ANIMAL & CELL MODELS |