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FLASH GENE
Symbol TAGLN contributors: mct/npt - updated : 24-08-2017
HGNC name transgelin
HGNC id 11553
Location 11q23.2      Physical location : 117.070.039 - 117.075.507
Synonym name
  • actin associated protein SM22 alpha
  • smooth muscle protein 22-alpha
  • transgelin variant 2
  • Synonym symbol(s) SM22, SMCC, WS3-10 , SM22A, TAGLN1, DKFZp686P11128
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC13125 11q23.3 hypothetical protein MGC13125 ZNF259 11q23.3 zinc finger protein 259 APOA5 11q23 apolipoprotein A-V APOA4 11q23.3 apolipoprotein A-IV APOC3 11q23.1-q23.2 apolipoprotein C-III APOA1 11q23.3 apolipoprotein A-I KIAA0999 11q23.3 apolipoprotein A-I LOC196266 11q23.3 similar to Proprotein convertase subtilisin/kexin type 7 precursor (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase) PAFAH1B2 11q23 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa CGI-40 11q23.3 CGI-40 protein TAGLN 11q23.2 transgelin PCSK7 11q23 proprotein convertase subtilisin/kexin type 7 DKFZp547C195 11q23.3 hypothetical protein DKFZp547C195 BACE 11q23.2-q23.3 beta-site APP-cleaving enzyme KIAA1052 11q23.3 KIAA1052 protein DSCAML1 11q23 Down syndrome cell adhesion molecule like 1 FXYD2 11q23,3 FXYD domain containing ion transport regulator 2 FXYD6 11q23.3 FXYD domain containing ion transport regulator 6
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1177 22.6 201 - Yang (2007)
    5 - 1574 22.6 201 - Yang (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose  highly
    Connectivebone  highly
    Muscularsmooth   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, ageing
    Text senescence fibroblasts, muscle (cardiac, smooth, skeletal)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nuclear factor binding motifs
  • a calponin-homology (CH) domain
  • conjugated Other
    HOMOLOGY
    interspecies ortholog to murine Tagln
    homolog to C.elegans F43G9.9
    Homologene
    FAMILY
  • family of actin-binding proteins
  • calponin family
  • CATEGORY motor/contractile , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a transformation and shape-change sensitive actin cross-linking/gelling protein
  • involved in calcium interactions and contractile properties of the cell contributing to replicative senescence
  • functioning as a suppressor via inhibition of RNF14-enhanced androgen receptor transactivation
  • regulator of MMP9 expression (repressor of 92-kDa type IV collagenase (MMP-9) expression)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to actin
  • binds to actin (multiple regions within the COOH-terminal domain are required for full actin affinity)
  • RNF14-associated negative modulator for AR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in aortic dissection
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS