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FLASH GENE
Symbol TAGLN contributors: mct/npt - updated : 24-08-2017
HGNC name transgelin
HGNC id 11553
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectiveadipose  highly
Connectivebone  highly
Muscularsmooth   
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, ageing
Text senescence fibroblasts, muscle (cardiac, smooth, skeletal)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear factor binding motifs
  • a calponin-homology (CH) domain
  • conjugated Other
    HOMOLOGY
    interspecies ortholog to murine Tagln
    homolog to C.elegans F43G9.9
    Homologene
    FAMILY
  • family of actin-binding proteins
  • calponin family
  • CATEGORY motor/contractile , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a transformation and shape-change sensitive actin cross-linking/gelling protein
  • involved in calcium interactions and contractile properties of the cell contributing to replicative senescence
  • functioning as a suppressor via inhibition of RNF14-enhanced androgen receptor transactivation
  • regulator of MMP9 expression (repressor of 92-kDa type IV collagenase (MMP-9) expression)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to actin
  • binds to actin (multiple regions within the COOH-terminal domain are required for full actin affinity)
  • RNF14-associated negative modulator for AR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in aortic dissection
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS