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FLASH GENE
Symbol TAF4 contributors: mct - updated : 24-05-2014
HGNC name TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
HGNC id 11537
Location 20q13.33      Physical location : 60.549.854 - 60.640.866
Synonym name
  • TBP associated factor 4
  • TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD
  • transcription initiation factor TFIID 135 kD subunit
    • Synonym symbol(s) TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135, FLJ41943
    DNA
    TYPE functioning gene
    STRUCTURE 91.01 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure TATA box binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4647 - 1085 - 2013 2409834
    - splicing - - - - 2013 2409834
  • isoform with the deleted hTAF4-TAFH domain repress proliferation of hMSCs and preferentially promote chondrogenic differentiation at the expense of other developmental pathways
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrineparathyroid   highly
    Nervousbrain   lowly
    Respiratorylung   highly
     respiratory tracttrachea  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • TAF homology domain
  • TAFH (NHR1) domain, and inactivation of hTAF4-TAFH domain accelerates differentiation of human neural progenitor cells
  • central region homologous to TAF2C2
  • C terminal domain
    • HOMOLOGY
    interspecies homolog to murine Taf4a
    intraspecies homolog to TAF2C2
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • RNA polymerase 2 transcription factor, coactivator involved in cAMP response element binding protein (CREB) dependent transcriptional activation
  • playing a specific role in transcription activation from a TATA-less, DPE containing promoter that is not observed with a TATA-containing, DPE-less promoter
  • nucleating a core subcomplex of TBP and mediating activated transcription from a TATA-less promoter
  • having coactivator function for E proteins that involves enhanced TBP binding
  • specific isoforms of TAF4 may selectively and efficiently control neurogenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • SP1 and huntingtin transcriptional activation function of these factors
  • CREB
  • DNA binding by TAF4/TAF4B-TAF12 facilitates the association of TBP with the core promoter of a subset of genes
  • binding poly Q stretches inhibiting CREB dependent transcriptional activation
  • TAF4B cooperates with POU5F1 to regulate a subset of genes in ESC, whereas TAF4 is required for later embryonic developmental stages
  • TBP subunit TAF4 is essential to restrain the growth promoting properties of COL6A3
  • involvement of TP53 and noncanonical WNT signaling pathways in mediating effects of TAF4 on neuronal differentiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS