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FLASH GENE
Symbol TAF4 contributors: mct - updated : 24-05-2014
HGNC name TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
HGNC id 11537
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrineparathyroid   highly
Nervousbrain   lowly
Respiratorylung   highly
 respiratory tracttrachea  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TAF homology domain
  • TAFH (NHR1) domain, and inactivation of hTAF4-TAFH domain accelerates differentiation of human neural progenitor cells
  • central region homologous to TAF2C2
  • C terminal domain
  • HOMOLOGY
    interspecies homolog to murine Taf4a
    intraspecies homolog to TAF2C2
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • RNA polymerase 2 transcription factor, coactivator involved in cAMP response element binding protein (CREB) dependent transcriptional activation
  • playing a specific role in transcription activation from a TATA-less, DPE containing promoter that is not observed with a TATA-containing, DPE-less promoter
  • nucleating a core subcomplex of TBP and mediating activated transcription from a TATA-less promoter
  • having coactivator function for E proteins that involves enhanced TBP binding
  • specific isoforms of TAF4 may selectively and efficiently control neurogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • SP1 and huntingtin transcriptional activation function of these factors
  • CREB
  • DNA binding by TAF4/TAF4B-TAF12 facilitates the association of TBP with the core promoter of a subset of genes
  • binding poly Q stretches inhibiting CREB dependent transcriptional activation
  • TAF4B cooperates with POU5F1 to regulate a subset of genes in ESC, whereas TAF4 is required for later embryonic developmental stages
  • TBP subunit TAF4 is essential to restrain the growth promoting properties of COL6A3
  • involvement of TP53 and noncanonical WNT signaling pathways in mediating effects of TAF4 on neuronal differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS