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FLASH GENE
Symbol TACSTD2 contributors: mct/shn - updated : 05-12-2011
HGNC name tumor-associated calcium signal transducer 2
HGNC id 11530
Corresponding disease
GDLD gelatinous drop-like corneal dystrophy
Location 1p32.1      Physical location : 59.041.096 - 59.043.166
Genatlas name pancreatic carcinoma marker protein GA7331
Synonym name
  • epithelial glycoprotein-1
  • membrane component, chromosome 1, surface marker 1
  • pancreatic carcinoma marker protein GA733-1
  • pancreatic carcinoma marker protein GA7331
  • cell surface glycoprotein Trop-2
  • cell surface glycoprotein TROP2
  • 40kD glycoprotein, identified by monoclonal antibody GA733
  • gastrointestinal tumor-associated antigen GA7331
  • Synonym symbol(s) CAA1, M1S1, EGP1, TROP2, GA773, GA733-1, GDLD , TTD2
    DNA
    TYPE like-sequence
    SPECIAL FEATURE
    text intronless
    STRUCTURE 2.07 kb     1 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    text structure intronless
    MAPPING cloned Y linked   status confirmed
    Map pter - D1S405 - D1S2648 - TACSTD2 - D1S2752 - D1S2700 - cen
    Physical map
    PCSK9 1p32.3 proprotein convertase subtilisin/kexin type 9 USP24 1p32.2-p31.2 ubiquitin specific protease 24 LOC388634 1 similar to Ubiquitin carboxyl-terminal hydrolase 24 (Ubiquitin thiolesterase 24) (Ubiquitin-specific processing protease 24) (Deubiquitinating enzyme 24) LOC388635 1 LOC388635 LOC391042 1 similar to glycogenin LOC391043 1 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2) LOC127406 1p32.2 similar to 33K laminin receptor homolog - bovine PPAP2B 1pter-p22.1 phosphatidic acid phosphatase type 2B PRKAA2 1p31 protein kinase, AMP-activated, alpha 2 catalytic subunit LOC199920 1p32.2 hypothetical protein LOC199920 C8A 1p32 complement component 8, alpha polypeptide C8B 1p32 complement component 8, beta polypeptide DAB1 1p32-p31 disabled homolog 1 (Drosophila) MPRP-1 1p32.1 metalloprotease related protein 1 TACSTD2 1p32-p31 tumor-associated calcium signal transducer 2 AK2B 1p32.1 adenylate kinase 2 pseudogene KIAA1915 1p32.1 KIAA1915 protein JUN 1p32-p31 v-jun sarcoma virus 17 oncogene homolog (avian) LOC391044 1 similar to prohibitin FLJ10986 1p32.1 hypothetical protein FLJ10986 HOOK1 1p32.1 hook homolog 1 (Drosophila) CYP2J2 1p31.3-p31.2 cytochrome P450, family 2, subfamily J, polypeptide 2 MGC34837 1p32.1 hypothetical protein MGC34837 NFIA 1p31.3-p31.2 nuclear factor I/A BBP 1p32.1 beta-amyloid binding protein precursor INADL 1p32.1-p31.3 beta-amyloid binding protein precursor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2080 35 323 - 1999 10192395
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Reproductivefemale systemovary  highly
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningepidermisstratum basale 
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage normal trophoblast cells
    cell lines carcinoma cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text trophoblast, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single transmembrane domain
  • EGF-like and thyroglobulin repeats
  • four potential N-linked glycosylation sites
  • a phosphatidylinositol binding site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Tacstd2, Mus musculus
    ortholog to Tacstd2, Rattus norvegicus
    ortholog to TACSTD2, Pan troglodytes
    intraspecies homolog to GA733.2
    Homologene
    FAMILY thyroglobulin type-1 family
    CATEGORY adhesion , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may play a role in regulating the growth of carcinoma cells (
  • carcinoma associated antigen
  • transducing an intracellular calcium signal and acting as a cell surface receptor
  • functioning as a cell/cell adhesion receptor in cancer cells and as a calcium signal transducer
  • its expression is necessary for tumorigenesis and invasiveness of colon cancer cells
  • activating a molecular signaling pathway which has important implications for cancer cell growth and survival
  • its upregulation quantitatively stimulates human cancer growth
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/vision
    calcium signal tranducer
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • non-structural 5A, NS5A (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDLD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with CCND1 and overexpressed in cancer cells
    tumoral     --over  
    in epithelial ovarian cancer
    tumoral     --over  
    correlates with poor prognosis in pancreatic cancer (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a novel prognostic biomarker for pancreatic cancer (
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    targeting of its overexpression by immunotherapeutic strategies may represent an attractive and potentially effective approach in patients harbouring epithelial ovarian cancer
    cancerendocrinepancreas
    might be a useful treatment approach for patients with pancreatic cancer overexpressing this cell-surface marker
    cancer  
    oncogene that has potential as a therapeutic target, and having a restricted expression in normal tissue, anti-Trop-2 therapeutics would be predicted to have limited toxicity
    ANIMAL & CELL MODELS