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FLASH GENE
Symbol TACSTD2 contributors: mct/shn - updated : 21-06-2023
HGNC name tumor-associated calcium signal transducer 2
HGNC id 11530
ASSOCIATED DISORDERS
corresponding disease(s) GDLD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with CCND1 and overexpressed in cancer cells
tumoral     --over  
in epithelial ovarian cancer
tumoral     --over  
correlates with poor prognosis in pancreatic cancer (
constitutional     --over  
may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs
tumoral     --over  
are predictive of recurrence of localized prostate cancer, castration-resistant prostate cancer (CRPC), or neuroendocrine prostate cancer (NEPC)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • could be a novel prognostic biomarker for pancreatic cancer (
  • could be used as a marker for pathological grading of squamous cell carcinoma (SCC)
  • TACSTD2 may be a valuable prognosis predictive biomarker in human solid tumors
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    targeting of its overexpression by immunotherapeutic strategies may represent an attractive and potentially effective approach in patients harbouring epithelial ovarian cancer
    cancerendocrinepancreas
    might be a useful treatment approach for patients with pancreatic cancer overexpressing this cell-surface marker
    cancer  
    oncogene that has potential as a therapeutic target, and having a restricted expression in normal tissue, anti-Trop-2 therapeutics would be predicted to have limited toxicity
    cancerreproductiveprostate
    is a driver and therapeutic target for metastatic prostate cancer with neuroendocrine phenotype
    cancerdigestivecolon
    is a target in metastatic colon cancer
    cancer  
    potential therapeutic target in human solid tumors
    ANIMAL & CELL MODELS