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FLASH GENE

Symbol

TACR3

contributors: mct/npt - updated : 27-03-2019

HGNC name	tachykinin receptor 3
HGNC id	11528

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HHGTR hypogonadotropic hypogonadism, familial
Location	4q24      Physical location : 104.510.624 - 104.640.973
Synonym name	NK-3 receptor
	neurokinin beta receptor
	neuromedin-K receptor
Synonym symbol(s)	NK3R, TAC3RL, MGC148060, MGC148061, NKR, TAC3R, NKBR, HH11, NK-3R, NK3
EC.number	2.7.11.14

DNA

TYPE	functioning gene
STRUCTURE	130.35 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001059 5 - 1755 NP_001050 52.07 465 - 2016 27580802

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly Homo sapiens   brain diencephalon hypothalamus nucleus accumbens   Reproductive female system oviduct       Homo sapiens   female system ovary       Homo sapiens   female system uterus       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Nervous central       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	exclusively expressed in brain (Vassilatis 2003)

basic FUNCTION	involved in regulation of human reproductive function (Guran 2009)
	G-protein coupled receptor that is broadly distributed in the nervous system and exerts its diverse physiological actions through multiple signaling pathways
	activation of the TACR3 appears to recruit multiple pathways, including acetylation, and possibly histone deactylases, histone methylases, or DNA methylases to affect chromatin structure and gene expression
	TAC3/TACR3 have been implicated in the neuroendocrine control of GNRH1 release
	TAC3 and its preferred tachykinin receptor 3 (TACR3) are prominently detected in the central nervous system, playing significant roles in physiological development and specifically in the human reproductive system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	receptor for the tachykinin neurokinin 3 (neurokinin B)
	IRX6 can activate or repress transcription through Iroquois-binding sites found proximal to RCVRN, VSX1 and TACR3
	peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HHGTR

Susceptibility

to alcohol and cocaine dependence to nonobstructive azoospermia (NOA)

Variant & Polymorphism other	sequence variations in TACR3 contribute to the variation in more severe alcohol dependent individuals and those who are also cocaine dependent (Foroud 2008)
	rs2765 SNP predicted the degree of impairment of learning and memory in the aged humans
	stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia

Candidate gene	for a critical central regulator of human gonadal function
	TAC3/TACR3 system may provide a new avenue for the pharmacological manipulation of human fertility and the treatment of sex steroid–related diseases, such as cancers of the breast and prostate (Topaloglu 2009)
Marker	important target to predict and improve learning and memory performance in the aged organism
Therapy target
	System Type Disorder Pubmed cancer digestive   signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction cancer angiogenesis   might be a potential novel target for the anti-angiogenesis therapy

ANIMAL & CELL MODELS