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FLASH GENE
Symbol TACR3 contributors: mct/npt - updated : 27-03-2019
HGNC name tachykinin receptor 3
HGNC id 11528
Corresponding disease
HHGTR hypogonadotropic hypogonadism, familial
Location 4q24      Physical location : 104.510.624 - 104.640.973
Synonym name
  • NK-3 receptor
  • neurokinin beta receptor
  • neuromedin-K receptor
  • Synonym symbol(s) NK3R, TAC3RL, MGC148060, MGC148061, NKR, TAC3R, NKBR, HH11, NK-3R, NK3
    EC.number 2.7.11.14
    DNA
    TYPE functioning gene
    STRUCTURE 130.35 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1755 52.07 465 - 2016 27580802
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly Homo sapiens
     braindiencephalonhypothalamusnucleus accumbens 
    Reproductivefemale systemoviduct    Homo sapiens
     female systemovary    Homo sapiens
     female systemuterus    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text exclusively expressed in brain (Vassilatis 2003)
    basic FUNCTION
  • involved in regulation of human reproductive function (Guran 2009)
  • G-protein coupled receptor that is broadly distributed in the nervous system and exerts its diverse physiological actions through multiple signaling pathways
  • activation of the TACR3 appears to recruit multiple pathways, including acetylation, and possibly histone deactylases, histone methylases, or DNA methylases to affect chromatin structure and gene expression
  • TAC3/TACR3 have been implicated in the neuroendocrine control of GNRH1 release
  • TAC3 and its preferred tachykinin receptor 3 (TACR3) are prominently detected in the central nervous system, playing significant roles in physiological development and specifically in the human reproductive system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for the tachykinin neurokinin 3 (neurokinin B)
  • IRX6 can activate or repress transcription through Iroquois-binding sites found proximal to RCVRN, VSX1 and TACR3
  • peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHGTR
    Susceptibility
  • to alcohol and cocaine dependence
  • to nonobstructive azoospermia (NOA)
  • Variant & Polymorphism other
  • sequence variations in TACR3 contribute to the variation in more severe alcohol dependent individuals and those who are also cocaine dependent (Foroud 2008)
  • rs2765 SNP predicted the degree of impairment of learning and memory in the aged humans
  • stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia
  • Candidate gene
  • for a critical central regulator of human gonadal function
  • TAC3/TACR3 system may provide a new avenue for the pharmacological manipulation of human fertility and the treatment of sex steroid–related diseases, such as cancers of the breast and prostate (Topaloglu 2009)
  • Marker
  • important target to predict and improve learning and memory performance in the aged organism
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestive 
    signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction
    cancerangiogenesis 
    might be a potential novel target for the anti-angiogenesis therapy
    ANIMAL & CELL MODELS