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FLASH GENE
Symbol TACR3 contributors: mct/npt - updated : 27-03-2019
HGNC name tachykinin receptor 3
HGNC id 11528
ASSOCIATED DISORDERS
corresponding disease(s) HHGTR
Susceptibility
  • to alcohol and cocaine dependence
  • to nonobstructive azoospermia (NOA)
  • Variant & Polymorphism other
  • sequence variations in TACR3 contribute to the variation in more severe alcohol dependent individuals and those who are also cocaine dependent (Foroud 2008)
  • rs2765 SNP predicted the degree of impairment of learning and memory in the aged humans
  • stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia
  • Candidate gene
  • for a critical central regulator of human gonadal function
  • TAC3/TACR3 system may provide a new avenue for the pharmacological manipulation of human fertility and the treatment of sex steroid–related diseases, such as cancers of the breast and prostate (Topaloglu 2009)
  • Marker
  • important target to predict and improve learning and memory performance in the aged organism
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestive 
    signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction
    cancerangiogenesis 
    might be a potential novel target for the anti-angiogenesis therapy
    ANIMAL & CELL MODELS