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FLASH GENE
Symbol TACO1 contributors: mct/npt - updated : 29-10-2009
HGNC name translational activator of mitochondrially encoded cytochrome c oxidase I
HGNC id 24316
Corresponding disease
TACO1D Leigh syndrome with TACO1deficiency
Location 17q23.3      Physical location : 61.678.230 - 61.685.724
Synonym name
  • clone HQ0477 PRO0477p
  • coiled-coil domain containing 44
    • Synonym symbol(s) PRO0477, CCDC44
    DNA
    TYPE functioning gene
    STRUCTURE 7.48 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1491 32.5 297 - Weraarpachai (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • coiled-coil domain
  • a conserved DUF28 domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • first specific mitochondrial translational activator and being clearly necessary for the efficient translation of COX I (Weraarpachai 2009)
  • might act by securing an accurate start of COX I translation, by stabilizing the elongating polypeptide and ensuring completion of its translation (Weraarpachai 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with other mitochondrial proteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TACO1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS