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FLASH GENE
Symbol SYNJ2 contributors: - updated : 03-05-2002
HGNC name synaptojanin 2
HGNC id 11504
Location 6q25.1-q25.2      Physical location : 158.402.887 - 158.520.205
Synonym name
  • inositol phophate 5'-phosphatase 2 (synaptojanin 2)
  • synaptic inositol-1,4,5-triphophate 5-phosphatase
    • Synonym symbol(s) KIAA0348, INPP5H, MGC44422
    EC.number 3.1.3.56
    DNA
    TYPE functioning gene
    STRUCTURE 117.00 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status confirmed
    Map cen - D6S442 - D6S1708 - SYNJ2 - D6S1612 - D6S1655 - D6S1581 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    text isoforms produced by alternative splicing
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SAC1 domain
  • a RNA recognition motif
  • a C terminal proline rich region
    • HOMOLOGY
    interspecies homolog to rattus synaptojanin
    homolog to murine Synj2
    homolog to C.elegans y38c9a.1
    Homologene
    FAMILY inosital-1,4,5-triphosphate 5-phosphatase family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • phosphatidylinositol-3,4,5-triphosphate 5-phosphatase
  • playing an essential role in synaptic vesicle recycling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    text synaptic vesicule endocytosis
    PATHWAY
    metabolism other
    signaling signal transduction
    phosphate metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein GRB2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS