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FLASH GENE
Symbol SYCE1 contributors: mct/npt - updated : 31-03-2009
HGNC name synaptonemal complex central element protein 1
HGNC id 28852
Location 10q26.3      Physical location : 135.367.403 - 135.382.876
Synonym name
  • chromosome 10 open reading frame 94
  • cancer/testis antigen 76
  • Synonym symbol(s) C10orf94, CT76, bA108K14.6, RP11-108K14.6
    DNA
    TYPE functioning gene
    STRUCTURE 15.47 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1452 36.1 318 - -
    14 - 1375 32.5 282 - Costa (2005)
    10 - 2336 - 190 - Costa (2005)
    - - 1309 39.6 351 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Lymphoid/Immunethymus   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • SYCE family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text localisation to the central element in the meiosis
    basic FUNCTION
  • playing a role in synaptonemal-complex assembly, and perhaps also stability and recombination
  • involved with SYCP1 and SYCE2 in synaptonemal complex assembly (Bolcun-Filas 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SYCE1 interacts more directly with SYCP1 and could thus anchor the central element proteins to the transverse filaments (Hamer 2006)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with the transverse filament protein SYCP1, and its localisation to the central element appears to depend on recruitment by SYCP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS