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FLASH GENE

Symbol

SYCE1

contributors: mct/npt - updated : 29-03-2021

HGNC name	synaptonemal complex central element protein 1
HGNC id	28852

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.39 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001143763 13 - 1402 NP_001137235 36.1 318 - 2019 30607510 NM_130784 13 - 1379 NP_570140 32.5 282 - 2019 30607510 variant 2 10 - 2336 - 190 - 2019 30607510 NM_001143764 13 - 1255 NP_001137236 39.6 351 - 2019 30607510

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Lymphoid/Immune thymus       highly Reproductive male system testis     highly Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

SYCE family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
text	localisation to the central element in the meiosis

basic FUNCTION	playing a role in synaptonemal-complex assembly, and perhaps also stability and recombination
	involved with SYCP1 and SYCE2 in synaptonemal complex assembly (Bolcun-Filas 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

SYCE1 interacts more directly with SYCP1 and could thus anchor the central element proteins to the transverse filaments (Hamer 2006)

INTERACTION

DNA

RNA

small molecule

protein	interact with the transverse filament protein SYCP1, and its localisation to the central element appears to depend on recruitment by SYCP1
	SYCE3 N-helix interacts with the SYCE1 C-helix, which is another central element component
	C14orf39 interacts with the well-established protein synaptonemal complex central element 1 (SYCE1)
	both SYCE1-SIX6OS1 binding interfaces are essential for SC assembly

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

POF12 , SPGF15

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS