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FLASH GENE
Symbol SVIP contributors: mlc/np - updated : 08-12-2007
Location 11p14.2      Physical location : 22.843.599 - 22.851.382
Genatlas name small VCP/p97-interacting protein
Synonym name hypothetical protein LOC258010
Synonym symbol(s) DKFZp313A2432
DNA
TYPE functioning gene
STRUCTURE 10.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1405 8.44 77 - Nagahama (2003)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
 pancreas   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal coiled-coil region
  • subsequent ATP-binding regions (ND1 domain)
  • potential myristoylation and palmitoylation sites
    • HOMOLOGY
    Homologene
    FAMILY
  • SVIP family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in a variety of cellular processes, including membrane fusion and ubiquitin-dependent protein degradation
  • VCP/p97 adaptor whose function is related to the integrity of the endoplasmic reticulum
  • endogenous inhibitor of ERAD (ER-associated degradation) that acts through regulating the assembly of the gp78-p97/VCP-Derlin1 complex, and may act to prevent excessive ERAD that may cause damage to cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS