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FLASH GENE
Symbol SVIP contributors: mlc/np - updated : 08-12-2007
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal coiled-coil region
  • subsequent ATP-binding regions (ND1 domain)
  • potential myristoylation and palmitoylation sites
    • HOMOLOGY
    Homologene
    FAMILY
  • SVIP family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in a variety of cellular processes, including membrane fusion and ubiquitin-dependent protein degradation
  • VCP/p97 adaptor whose function is related to the integrity of the endoplasmic reticulum
  • endogenous inhibitor of ERAD (ER-associated degradation) that acts through regulating the assembly of the gp78-p97/VCP-Derlin1 complex, and may act to prevent excessive ERAD that may cause damage to cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS