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FLASH GENE
Symbol STX3 contributors: mct - updated : 09-05-2013
HGNC name syntaxin 3
HGNC id 11438
Location 11q12.1      Physical location : 59.522.531 - 59.573.354
Synonym name syntaxin 3A
Synonym symbol(s) STX3A
DNA
TYPE functioning gene
STRUCTURE 50.82 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 6498 - 289 in nonneuronal tissues, such as kidney 2008 18683220
  • syntaxin 3A
  • with syntaxin 3B, have an identical N-terminal domain but differ in the C-terminal half of the SNARE domain and the C-terminal transmembrane domain
  • 10 splicing 6384 - 277 - 2008 18683220
  • syntaxin 3B
  • with syntaxin 3A, have an identical N-terminal domain but differ in the C-terminal half of the SNARE domain and the C-terminal transmembrane domain
  • can function as a t-SNARE
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine     Homo sapiens
    Urinarykidney     Homo sapiens
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    Digestiveenterocyte Homo sapiens
    Visualganglion cell Homo sapiens
    cell lineage
    cell lines neutrophil-differentiated HL-60, SH-SYSY neurblastoma cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • syntaxin family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    text
  • granule membranes
  • cycles between the plasma membrane and the trans-Golgi network
  • colocalized with CFTR on the apical domain of enterocytes (
  • basic FUNCTION
  • together with STXBP2 regulate degranulation positively during the process of membrane fusion between secretory granules and plasma membrane, rather than during processes that regulate the number or behavior of secretory granules
  • implicated in the trafficking of transport vesicles to the apical plasma membrane of polarized cells (
  • intestine-specific SNARE, necessary for cAMP- and cGMP-regulated exocytosis of CFTR
  • having an important role in the pathophysiology of enterotoxin-elicited diarrhea
  • STX3- and STX4-dependent integrin trafficking is important in cancer cell migration and survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of vesicle trafficking apparatus
  • assembled core SNARE complex consisting of STX3, SNAP23 and VAMP8
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CPLX2 (complexin II regulates degranulation by interacting with the SNARE complex containing STX3) (
  • CPLX2 interact with vesicle-associated membrane protein (VAMP2), syntaxins 3 and 4, but not with VAMP8 or syntaxin 2
  • STXBP2 binds STX3, VAMP8 and the assembled core SNARE complex consisting of STX3, SNAP23 and VAMP8
  • interacts with CFTR
  • SNARE machinery composed of VAMP7 on TYRP1-containing vesicles and STX3 and SNAP23 on melanosomes regulates TYRP1 trafficking to the melanosome in melanocytes
  • TGFB1 increased the association of SLC6A4 with the soluble STX3 and promoted exocytosis of SLC6A4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS