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FLASH GENE

Symbol

STX3

contributors: mct - updated : 09-05-2015

HGNC name	syntaxin 3
HGNC id	11438

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Homo sapiens Urinary kidney         Homo sapiens Visual eye retina       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Digestive enterocyte Homo sapiens Visual ganglion cell Homo sapiens

cell lineage
cell lines	neutrophil-differentiated HL-60, SH-SYSY neurblastoma cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

syntaxin family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic,granule
text	granule membranes
	cycles between the plasma membrane and the trans-Golgi network
	colocalized with CFTR on the apical domain of enterocytes (

basic FUNCTION	together with STXBP2 regulate degranulation positively during the process of membrane fusion between secretory granules and plasma membrane, rather than during processes that regulate the number or behavior of secretory granules
	implicated in the trafficking of transport vesicles to the apical plasma membrane of polarized cells (
	intestine-specific SNARE, necessary for cAMP- and cGMP-regulated exocytosis of CFTR
	having an important role in the pathophysiology of enterotoxin-elicited diarrhea
	STX3- and STX4-dependent integrin trafficking is important in cancer cell migration and survival

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

exocytosis transport , cellular trafficking transport

PATHWAY

metabolism

signaling

a component	component of vesicle trafficking apparatus
	assembled core SNARE complex consisting of STX3, SNAP23 and VAMP8

INTERACTION

DNA

RNA

small molecule

protein	interacting with CPLX2 (complexin II regulates degranulation by interacting with the SNARE complex containing STX3) (
	CPLX2 interact with vesicle-associated membrane protein (VAMP2), syntaxins 3 and 4, but not with VAMP8 or syntaxin 2
	STXBP2 binds STX3, VAMP8 and the assembled core SNARE complex consisting of STX3, SNAP23 and VAMP8
	interacts with CFTR
	SNARE machinery composed of VAMP7 on TYRP1-containing vesicles and STX3 and SNAP23 on melanosomes regulates TYRP1 trafficking to the melanosome in melanocytes
	secretion of IL1A, IL1B, IL12B, and CCL4 occurs during gelatinase degranulation, a process controlled by STX3
	TGFB1 increased the association of SLC6A4 with the soluble STX3 and promoted exocytosis of SLC6A4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS