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FLASH GENE
Symbol STMN3 contributors: mct/shn - updated : 03/03/2012
HGNC name stathmin-like 3
HGNC id 15926
Location 20q13.33      Physical location : 62.271.060 - 62.284.780
Synonym name
  • SCG10-like protein
  • SCG10-like-protein
  • stathmin-3
  • Synonym symbol(s) SCLIP
    DNA
    TYPE functioning gene
    STRUCTURE 13.72 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure two putative neuron-restricted silencer elements (NRSEs)
    MAPPING cloned Y linked N status provisional
    Map cen - D20S171 - D20S173 - STMN3 - qter
    Physical map
    C20orf21 20q13.33 chromosome 20 open reading frame 21 BIRC7 20q13.3 baculoviral IAP repeat-containing 7 (livin) C20orf58 20q13.33 chromosome 20 open reading frame 58 ARFGAP1 20q13.33 ADP-ribosylation factor GTPase activating protein 1 KIAA1510 20q13.33 KIAA1510 protein CHRNA4 20q13.2-q13.3 cholinergic receptor, nicotinic, alpha polypeptide 4 KCNQ2 20q13.3 potassium voltage-gated channel, KQT-like subfamily, member 2 EEF1A2 20q13.3 eukaryotic translation elongation factor 1 alpha 2 LOC149659 20q13.33 hypothetical LOC149659 C20orf149 20q13.33 chromosome 20 open reading frame 149 PTK6 20q13.3 PTK6 protein tyrosine kinase 6 SRMS 20q13.33 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites MGC5356 20q13.33 hypothetical protein MGC5356 PRIC285 20q13.33 peroxisomal proliferator-activated receptor A interacting complex 285 LOC200213 20q13.33 hypothetical protein LOC200213 GMEB2 20q13.33 glucocorticoid modulatory element binding protein 2 LOC388807 20 LOC388807 STMN3 20q13.3 stathmin-like 3 C20orf41 20q13.3 chromosome 20 open reading frame 41 TNFRSF6B 20q13.3 tumor necrosis factor receptor superfamily, member 6b, decoy ARFRP1 20q13.3 ADP-ribosylation factor related protein 1 KIAA1847 20q13.3 KIAA1847 FLJ20406 20q13.3 hypothetical protein FLJ20406 SLC2A4RG 20q13.33 SLC2A4 regulator FLJ20825 20q13.33 hypothetical protein FLJ20825 C20orf135 20q13.33 chromosome 20 open reading frame 135 TPD52L2 20q13.2-q13.3 tumor protein D52-like 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2255 21 180 Neuron specific 1998 9603203
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately Homo sapiens
    Digestiveintestinelarge intestinecolon moderately Homo sapiens
     liver   lowly Homo sapiens
     salivary gland   lowly Homo sapiens
    Endocrineadrenal gland   moderately Homo sapiens
     pancreas   moderately Homo sapiens
     thyroid   highly Homo sapiens
    Lymphoid/Immunespleen   moderately Homo sapiens
     thymus   highly Homo sapiens
    Nervousbrainhindbraincerebellum highly Homo sapiens
     brain   highly Homo sapiens
     spinal cord   highly Homo sapiens
    Reproductivefemale systemovary  moderately Homo sapiens
     female systemplacenta  moderately Homo sapiens
     female systemuterus  moderately Homo sapiens
     female systembreast  moderately Homo sapiens
     male systemtestis  moderately Homo sapiens
     male systemprostate  moderately Homo sapiens
    Urinarykidney   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately Homo sapiens
    Muscularstriatumskeletal lowly Homo sapiens
    Nervous   specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text
  • fetal brain, liver (
  • strongly expressed in Purkinje cells during cerebellar development and accumulates in their dendritic processes at a critical period of their formation and outgrowth
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal likely involved in membrane attachment
  • a C terminal stathmin like domain
  • HOMOLOGY
    interspecies ortholog to Stmn3, Mus musculus
    ortholog to Stmn3, Rattus norvegicus
    intraspecies homolog to SCG10
    Homologene
    FAMILY stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • at least partially associated to the Golgi apparatus
  • colocalized to the Golgi apparatus of chromaffin cells and shared localization with CHGA as it transited the Golgi
  • basic FUNCTION
  • able to depolymerize interphase microtubules when overexpressed
  • acts as microtubule destabilizers
  • playing a role in differentiated neurons
  • regulator of axonal branching in hippocampal neurons, and having a function in axonal morphogenesis
  • implicated in the development and functional regulation of various organs, most notably the nervous system
  • participate in the control of microtubule dynamics and may be involved in the control of neuronal differentiation
  • STMN2 and STMN3, interact with CHGA, share partial colocalization in the Golgi apparatus, and may be necessary for typical transmitter storage and release from chromaffin cells
  • crucial for both the formation and proper development of Purkinje cell dendritic arbors
  • novel and specific factor that controls the early phases of Purkinje cell dendritic differentiation during cerebellum development
  • palmitoylation of stathmins 3 likely occurs at the Golgi and is crucial for its specific subcellular localization and trafficking (
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text signal transduction and regulation of microtubule dynamics
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel RASGRF1-interacting protein, and influences the signaling properties of RASGRF1
  • CHGA and STMN2 (
  • STAT3 (
  • DHHC3, DHHC7, DHHC15, and DHHC17 (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS