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FLASH GENE
Symbol STMN3 contributors: mct/shn - updated : 03/03/2012
HGNC name stathmin-like 3
HGNC id 15926
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2255 21 180 Neuron specific 1998 9603203
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately Homo sapiens
Digestiveintestinelarge intestinecolon moderately Homo sapiens
 liver   lowly Homo sapiens
 salivary gland   lowly Homo sapiens
Endocrineadrenal gland   moderately Homo sapiens
 pancreas   moderately Homo sapiens
 thyroid   highly Homo sapiens
Lymphoid/Immunespleen   moderately Homo sapiens
 thymus   highly Homo sapiens
Nervousbrainhindbraincerebellum highly Homo sapiens
 brain   highly Homo sapiens
 spinal cord   highly Homo sapiens
Reproductivefemale systemovary  moderately Homo sapiens
 female systemplacenta  moderately Homo sapiens
 female systemuterus  moderately Homo sapiens
 female systembreast  moderately Homo sapiens
 male systemtestis  moderately Homo sapiens
 male systemprostate  moderately Homo sapiens
Urinarykidney   moderately Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately Homo sapiens
Muscularstriatumskeletal lowly Homo sapiens
Nervous   specific
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text
  • fetal brain, liver (
  • strongly expressed in Purkinje cells during cerebellar development and accumulates in their dendritic processes at a critical period of their formation and outgrowth
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal likely involved in membrane attachment
  • a C terminal stathmin like domain
  • HOMOLOGY
    interspecies ortholog to Stmn3, Mus musculus
    ortholog to Stmn3, Rattus norvegicus
    intraspecies homolog to SCG10
    Homologene
    FAMILY stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • at least partially associated to the Golgi apparatus
  • colocalized to the Golgi apparatus of chromaffin cells and shared localization with CHGA as it transited the Golgi
  • basic FUNCTION
  • able to depolymerize interphase microtubules when overexpressed
  • acts as microtubule destabilizers
  • playing a role in differentiated neurons
  • regulator of axonal branching in hippocampal neurons, and having a function in axonal morphogenesis
  • implicated in the development and functional regulation of various organs, most notably the nervous system
  • participate in the control of microtubule dynamics and may be involved in the control of neuronal differentiation
  • STMN2 and STMN3, interact with CHGA, share partial colocalization in the Golgi apparatus, and may be necessary for typical transmitter storage and release from chromaffin cells
  • crucial for both the formation and proper development of Purkinje cell dendritic arbors
  • novel and specific factor that controls the early phases of Purkinje cell dendritic differentiation during cerebellum development
  • palmitoylation of stathmins 3 likely occurs at the Golgi and is crucial for its specific subcellular localization and trafficking (
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text signal transduction and regulation of microtubule dynamics
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel RASGRF1-interacting protein, and influences the signaling properties of RASGRF1
  • CHGA and STMN2 (
  • STAT3 (
  • DHHC3, DHHC7, DHHC15, and DHHC17 (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS