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FLASH GENE
Symbol STAT5B contributors: mct/npt - updated : 05-07-2010
HGNC name signal transducer and activator of transcription 5B
HGNC id 11367
Corresponding disease
GHIS3 growth hormone insensitivity 3
Location 17q21.2      Physical location : 40.351.195 - 40.428.424
Synonym name transcription factor STAT5B
Synonym symbol(s) STAT5
DNA
TYPE functioning gene
STRUCTURE 77.23 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence alternative promoter
cytosine-phosphate-guanine/HTF
text structure an alternative tissue specific promoter
MAPPING cloned Y linked N status provisional
Physical map
MGC20781 17q21.31 hypothetical protein MGC20781 KLHL10 17q21.2 kelch-like 10 (Drosophila) FLJ10572 17q21.31 hypothetical protein FLJ10572 ACLY 17q21-q22 ATP citrate lyase DKFZP434H0115 17q21.31 hypothetical protein DKFZp434H0115 CNP 17q21 2',3'-cyclic nucleotide 3' phosphodiesterase DNAJC7 17q11.2 DnaJ (Hsp40) homolog, subfamily C, member 7 KBRAS2 17q21.31 I-kappa-B-interacting Ras-like protein 2 LOC201181 17q21.31 similar to hypothetical protein A930006D11 LOC390796 17 similar to hypothetical protein A930006D11 LGP2 17q21.2 similar to hypothetical protein A930006D11 GCN5L2 17q21 GCN5 general control of amino-acid synthesis 5-like 2 (yeast) HspB9 17q21.31 small heat shock protein B9 RAB5C 17q21 RAB5C, member RAS oncogene family KCNH4 17q21.31 potassium voltage-gated channel, subfamily H (eag-related), member 4 HCRT 17q21 hypocretin (orexin) neuropeptide precursor LGP1 17q21.2 hypocretin (orexin) neuropeptide precursor STAT5B 17q11.2 signal transducer and activator of transcription 5B STAT5A 17q11.2 signal transducer and activator of transcription 5A MGC16063 17q21.31 hypothetical protein MGC16063 STAT3 17q21 signal transducer and activator of transcription 3 (acute-phase response factor) PTRF 17q21.2 polymerase I and transcript release factor ATP6V0A1 17q21.3 ATPase, H+ transporting, lysosomal V0 subunit a isoform 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 5171 - 787 - Lin (1996)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunelymph node   highly
 thymus   highly
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
 fibroblast
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminus conserved domain,the coiled coil domain,
  • the DNA binding domain,a linker region,
  • a SRC homology domain 2 (SH2), a critical site of tyrosine phosphorylation
  • the carboxy-terminal transactivation domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • STAT family of transcription factors
  • CATEGORY immunity/defense , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text translocated into the nucleus in response to phosphorylation
    basic FUNCTION
  • regulator of transcription having a dual function: signal transduction and activation of transcription
  • functioning to transduce signals from cytokines to the nucleus where it regulates gene expression
  • playing a crucial role in mammary epithelium displaying reciprocal activation kinetics during pregnancy, lactation and involution
  • signal transducer and activator of transcription 5A and 5B (STAT5A/B) is critical for the viability of prostate cancer cells (Tan 2008)
  • potential role of the STAT5B-RUNX interaction in lymphocyte development
  • STAT5A/B directs GM-CSF signaling through the regulation of proliferation and survival genes (Kimura 2009)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homodimerizing or heterodimerizing with STAT5A
  • PLCB3 form the multimolecular SPS complex together with PTPN6 and STAT5
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the NCAM2 intron in the NKL natural killer cell line (this binding is induced by cytokines that activate STAT5B)
  • physically interacts with RUNX1, RUNX2 and RUNX3
  • BCL10 is an IL2-independent STAT5B target gene
  • functions for GAB2 in hematopoiesis in a manner that is non-redundant with STAT5B
  • LYN/PLCB3-mediated regulatory mechanism of PTPN6 and STAT5B activities
  • key regulator of lymphoid development, that is modified by SUMO-2 and is specifically regulated by SENP1
  • crucial role of SENP1 in the regulation of STAT5B activation during early lymphoid development
  • cell & other
  • T cell receptor and stimulating T cell proliferation
  • REGULATION
    activated by interleukin 2 and other cytokines
    GH, strongly activated by prolactin (PRL) towards the end of pregnancy, persists in an activated state during lactation, and is rapidly inactivated after cessation of suckling
    repressed by NCOR2
    Other its signaling can be modulated by its coupling with a specific subset of G protein subunits, revealing a novel signaling mechanism for the transcriptional regulation of STAT5B-dependent genes (Georganta 2010)
    regulated by SRC (SRC may regulate STAT5B in the intracellular signalling pathway important for the proliferation of normal human B lymphocytes)(Cayer 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) GHIS3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RARA, 5' - STAT5B - RARA - 3', in a small subset of acute promyelocytic leukemias
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    inhibitors that disrupt STAT5B function independent of tyrosine phosphorylation may be therapeutically effective in treating certain leukemias/lymphomas
    ANIMAL & CELL MODELS