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FLASH GENE

Symbol

STAT5B

contributors: mct/npt - updated : 24-02-2018

HGNC name	signal transducer and activator of transcription 5B
HGNC id	11367

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

GHIS3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with RARA, 5' - STAT5B - RARA - 3', in a small subset of acute promyelocytic leukemias

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   inhibitors that disrupt STAT5B function independent of tyrosine phosphorylation may be therapeutically effective in treating certain leukemias/lymphomas

ANIMAL & CELL MODELS