SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome,nucleosome
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basic FUNCTION
| complex required for the cohesion of sister chromatids after DNA replication |
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may also play a role in spindle pole assembly during mitosis |
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able to enhance the activity of the tumor necrosis factor alpha, the CD69, and the human immunodeficiency virus long terminal repeat promoters in a NF-kappaB-dependent manner |
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role for STAG/Scc3 in transcriptional regulation |
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its phosphorylation is essential for cohesin dissociation during prophase and prometaphase, but is not required for cohesin cleavage by separase |
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maintaining sister chromatid cohesion during the diplotene stage of meiosis |
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cohesin(STAG1) and cohesin(STAG2) are differentially required for telomere and centromere cohesion, respectively |
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component of the cohesin complex identified as a candidate gene that could participate in XCI through its association with CTCF |
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regulates the separation of sister chromatids during cell division |
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likely to function as a “caretaker” tumor suppressor gene that when inactivated results in chromosomal instability, similar to other caretaker genes like MLH1 and MSH2 that, when inactivated, result in nucleotide instability |
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STAG2, RAD21, SMC1A, SMC3 mutations participate in leukemogenesis through the deregulated expression of genes that are involved in myeloid development and differentiation |
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STAG1 and STAG2 participate in the DNA damage response, coordinately protecting genome integrity in human cells through unique ways |
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STAG2 promotes the correction of kinetochore-microtubule (kMT) attachment errors to ensure faithful chromosome segregation during mitosis |
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is a dosage-sensitive gene and heterozygous loss-of-function variants lead to a cohesinopathy |
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STAG1 and STAG2 share high sequence identity, encode mutually exclusive cohesin subunits and retain partially overlapping functions |
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cohesin ring is a protein complex composed of four core subunits: SMC1A, SMC3, RAD21 and STAG1/STAG2 and is involved in chromosome segregation, DNA repair, chromatin organization and transcription regulation |
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STAG1 is required for telomere cohesion and STAG2 for centromere cohesion |
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STAG2 functions likely at intermediate DNA structures during DNA transactions in genome maintenance pathways |
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predominantly functions in sister chromatid cohesion and segregation |