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FLASH GENE
Symbol STAG2 contributors: mct - updated : 13-06-2018
HGNC name stromal antigen 2
HGNC id 11355
ASSOCIATED DISORDERS
corresponding disease(s) SRXID
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
in STAG2-depleted cells telomere cohesion is normal, but centromere cohesion is prematurely lost
tumoral somatic mutation      
in myelodysplastic syndromes, chronic myelogenous leukemia , chronic myelomonocytic leukemia and acute myeloid leukemia
constitutional germinal mutation     loss of function
in a syndrome with developmental delay, microcephaly, microtia with hearing loss, language delay, ADHD, and dysmorphic features
constitutional        
STAG2 silencing in normal human cells that lack telomerase led to increased recombination at telomeres, delayed telomere shortening, and postponed senescence onset
tumoral     --other  
abnormal expression of STAG2 could cause aneuploidy in normal bladder cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS