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FLASH GENE
Symbol SSTR5 contributors: npt/mct/pgu - updated : 16-09-2015
HGNC name somatostatin receptor 5
HGNC id 11334
Location 16p13.3      Physical location : 1.122.755 - 1.131.454
Synonym name somatostatin receptor subtype 5
Synonym symbol(s) SS5R
DNA
TYPE functioning gene
STRUCTURE 1.09 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
MGC2601 16p13.3 hypothetical protein MGC2601 MGC2494 16p13.3 hypothetical protein MGC2494 FLJ34512 16p13.3 hypothetical protein FLJ34512 HAGHL 16p13.3 hydroxyacyl glutathione hydrolase-like NARFL 16p13.3 nuclear prelamin A recognition factor-like MSLN 16p13.3 mesothelin RLUCL CHTF18 16p13.3 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) GNG13 16p13.3 guanine nucleotide binding protein (G protein), gamma 13 LOC388199 16 LOC388199 FLJ12681 16p13.3 hypothetical protein FLJ12681 SOX8 16p13.33 SRY (sex determining region Y)-box 8 FLJ32252 16p13.3 hypothetical protein FLJ32252 SSTR5 16p13.3 somatostatin receptor 5 LOC390663 16 similar to Williams-Beuren syndrome critical region protein 25 LOC390664 16 similar to C1q Related CACNA1H 16p13.3 calcium channel, voltage-dependent, alpha 1H subunit TPS1 16p13.3 tryptase, alpha TPSB2 16p13.3 tryptase beta 2 TPSG1 16p13.3 tryptase gamma 1 TPSB1 16p13.3 tryptase beta 1 TPSD1 16p13.3 tryptase delta 1 ISP2 16p13.3 implantation serine proteinase 2 LOC123788 16p13.3 similar to mast cell protease-11 UBE2I 16p13.3 ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1095 39.1 364 - 2009 19342453
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary  
Endocrinepancreas   highly
Nervousnervecranial nerve   
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pituitary and hypothalamus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • DRY motif in the second intracellular loop (role in intracellular signaling)
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • ZDHHC5 and SSTR5 are colocalized at the plasma membrane
  • basic FUNCTION
  • acting at many sites to inhibit the release of many hormones and other secretory proteins
  • required for the activation of different signaling pathways through its different regions
  • SSTR2 and SSTR5 are important markers in the regulation and development of Sertoli cell
  • whereas SSTR2 might play a primary role in the differentiation and regulation of TSH, LH, and FSH cells, SSTR5 appear to be mainly involved in GH regulation from birth onward
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • could both homodimerize and heterodimerize with SSTR1 in the presence of the agonist SST14 (activation of SSTR5 but not SSTR1 is necessary for heterodimeric assembly)
  • heterodimerize with SSTR2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the N-terminal region of the putative palmitoyltransferase ZDHHC5
  • cell & other
    REGULATION
    Other palmitoylated by the interacting ZDHHC5 palmitoyltransferase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in an acromegalic patient resistant to somatostatin analog treatment
    Susceptibility to acromegaly
    Variant & Polymorphism other role for SSTR5 t-461c and c1004t alleles in influencing GH and IGF-I levels in patients with acromegaly
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS