Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SSTR5 contributors: npt/mct/pgu - updated : 16-09-2015
HGNC name somatostatin receptor 5
HGNC id 11334
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1095 39.1 364 - 2009 19342453
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
endocrinebraindiencephalonpituitary  
Endocrinepancreas   highly
Nervousnervecranial nerve   
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pituitary and hypothalamus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • DRY motif in the second intracellular loop (role in intracellular signaling)
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • ZDHHC5 and SSTR5 are colocalized at the plasma membrane
  • basic FUNCTION
  • acting at many sites to inhibit the release of many hormones and other secretory proteins
  • required for the activation of different signaling pathways through its different regions
  • SSTR2 and SSTR5 are important markers in the regulation and development of Sertoli cell
  • whereas SSTR2 might play a primary role in the differentiation and regulation of TSH, LH, and FSH cells, SSTR5 appear to be mainly involved in GH regulation from birth onward
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • could both homodimerize and heterodimerize with SSTR1 in the presence of the agonist SST14 (activation of SSTR5 but not SSTR1 is necessary for heterodimeric assembly)
  • heterodimerize with SSTR2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the N-terminal region of the putative palmitoyltransferase ZDHHC5
  • cell & other
    REGULATION
    Other palmitoylated by the interacting ZDHHC5 palmitoyltransferase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in an acromegalic patient resistant to somatostatin analog treatment
    Susceptibility to acromegaly
    Variant & Polymorphism other role for SSTR5 t-461c and c1004t alleles in influencing GH and IGF-I levels in patients with acromegaly
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS