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FLASH GENE

Symbol

SSR4

contributors: mct - updated : 09-01-2019

HGNC name	signal sequence receptor, delta (translocon-associated protein delta)
HGNC id	11326

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CDG1Y congenital disorder of glycosylation, type I Y
Location	Xq28      Physical location : 153.060.093 - 153.063.953
Synonym name	translocon associated protein, delta subunit
	TRAP-delta
Synonym symbol(s)	TRAPD

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head, opposite orientation
text	head to head IDH3G
STRUCTURE	3.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
text structure	CpG island shared with IDH3G

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - IDH3G - SSR4 - qter
Authors	Brenner (97)
Text	see L1CAM

RNA

TRANSCRIPTS	type	messenger

text	an alternatively polyadenylation site (Brenner)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001204527 7 - 777 NP_001191456 - 181 - 2015 26264460 NM_001204526 7 - 754 NP_001191455 - 184 - 2015 26264460 NM_006280 6 - 727 NP_006271 - 173 - 2015 26264460

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Lymphoid/Immune spleen         Nervous brain         Reproductive female system placenta

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , tetramer

HOMOLOGY

interspecies	homolog to rattus Ssr4
	ortholog to monodelphis Trapd

Homologene

FAMILY

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION

member of a complex whose function is to bind calcium to the ER membrane and regulating the retention of ER resident proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterotetramer of trap-alpha, trap-beta, trap-delta and trap-gamma

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDG1Y

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in tumours of advanced stages(in ultraviolet B-induced melanoma)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS