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FLASH GENE
Symbol SRP68 contributors: mct - updated : 09-05-2012
HGNC name signal recognition particle 68kDa
HGNC id 11302
Location 17q25.1      Physical location : 74.035.190 - 74.068.607
DNA
TYPE functioning gene
STRUCTURE 33.42 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CASKIN2 17q25.3 CASK interacting protein 2 LOC283989 17q25.3 hypothetical protein LOC283989 LLGL2 17q24-q25 lethal giant larvae homolog 2 (Drosophila) MYO15B 17q25 myosin XVB, pseudogene LOC390815 17 similar to Myosin XV (Unconventional myosin-15) RECQL5 17q25 RecQ protein-like 5 HCNGP 17q25.3 transcriptional regulator protein ITGB4 17q24.3 integrin, beta 4 GALK1 17q24 galactokinase 1 H3F3B 17q25 H3 histone, family 3B (H3.3B) KIAA1753 17q25.3 KIAA1753 protein UNC13D 17q25.3 unc-13 homolog D (C. elegans) WBP2 17q25 WW domain binding protein 2 TRIM47 17q24.q25 tripartite motif-containing 47 LOC201292 17q25.3 hypothetical protein LOC201292 MRPL38 17q23-q25 mitochondrial ribosomal protein L38 FBF-1 17q25.3 Fas binding protein 1 ACOX1 17q25.1 acyl-Coenzyme A oxidase 1, palmitoyl CDK3 17q25 cyclin-dependent kinase 3 EVPL 17q24.2-q24.3 envoplakin SRP68 17q25,1 signal recognition particle 68kDa GALR2 17q25.3 galanin receptor 2 LGICZ 17q25.3 ligand-gated ion channel subunit EXO70 17q25.3 ligand-gated ion channel subunit FOXJ1 17q forkhead box J1 KIAA1917 17q25.3 KIAA1917 protein MGC29814 17q25.3 hypothetical protein MGC29814 DKFZP434P0316 17q25.3 hypothetical protein DKFZp434P0316 PRPSAP1 17q24-q25 phosphoribosyl pyrophosphate synthetase-associated protein 1 SPHK1 17q25.2 sphingosine kinase 1 E2-230K 17q25.1 likely ortholog of mouse ubiquitin-conjugating enzyme E2-230K AANAT 17q25 arylalkylamine N-acetyltransferase FLJ22341 17q25.3 hypothetical protein FLJ22341 CYGB 17q25.3 cytoglobin
regionally located in the Smith-Magenis critical reigon
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 2515 68 627 - 2006 16672232
- - 2736 - 589 - 2006 16672232
- - 2045 - 288 - 2006 16672232
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA binding domain located near the N-terminus
  • large SRP domain directly and/or indirectly engaged in the binding of SRP68
  • ninety-four AA near the C terminus mediated the binding to SRP72
  • conjugated RiboP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila Cg5064
    intraspecies homolog to sequences found in the SMS repeat gene clusters SMS-REPD,SMS-REPM,REPP (see symbols)
    Homologene
    FAMILY SRP family of GTP binding proteins
    CATEGORY RNA associated , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    basic FUNCTION interacting directly with the docking protein in the endoplasmic reticulum membrane and participating possibly in the elongation arrest function
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex(SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
  • SRP68 and SRP72, form a stable SRP68/72 heterodimer of unknown structure which is required for SRP function
  • INTERACTION
    DNA
    RNA required for the binding of SRP72 to 7S RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS