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FLASH GENE
Symbol SRP68 contributors: mct - updated : 09-05-2012
HGNC name signal recognition particle 68kDa
HGNC id 11302
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA binding domain located near the N-terminus
  • large SRP domain directly and/or indirectly engaged in the binding of SRP68
  • ninety-four AA near the C terminus mediated the binding to SRP72
    • conjugated RiboP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila Cg5064
    intraspecies homolog to sequences found in the SMS repeat gene clusters SMS-REPD,SMS-REPM,REPP (see symbols)
    Homologene
    FAMILY SRP family of GTP binding proteins
    CATEGORY RNA associated , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    basic FUNCTION interacting directly with the docking protein in the endoplasmic reticulum membrane and participating possibly in the elongation arrest function
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex(SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
  • SRP68 and SRP72, form a stable SRP68/72 heterodimer of unknown structure which is required for SRP function
    • INTERACTION
    DNA
    RNA required for the binding of SRP72 to 7S RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS