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FLASH GENE
Symbol SRI contributors: mct/pgu - updated : 02-05-2012
HGNC name sorcin
HGNC id 11292
Location 7q21.12      Physical location : 87.834.431 - 87.856.308
Synonym name
  • calcium binding protein amplified in mutlidrug-resistant cells
  • soluble resistance-related calcium-binding protein
    • Synonym symbol(s) SCN, FLJ26259
    DNA
    TYPE functioning gene
    STRUCTURE 21.88 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D7S2622 - D7S574 - (D7S2625 - D7S159 , D7S621 ),(ADAM22 , SCNEDL , CROT , D7S2621 ) - D7S1646 - ABCB4 - ABCB1 - D7S2624 - D7S2628 - D7S1642 - D7S2623 - NADHDL1 - SRI - ADAM22 - D7S2672 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2030 22 198 - 2008 17699613
  • more abundant isoform of sorcin expressed in colorectal cancer
    • 8 - 2012 20.3 183 - 2008 17699613
    - - 932 - 195 - 2008 17699613
    isoform C
    - - 908 - 180 - 2008 17699613
    isoform D
    - - - 18 - - 2011 22052463
  • mitochondrial isoform reported to participate in antiapoptosis in colorectal cancer
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     stomach   highly
    Nervousbrain   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five EF hand calcium binding domains
  • a interacting surface mapped on the C-terminal Ca(2+)-binding domain in the D helix region comprising W99, the interaction zone with SLC8A1
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans m04f3.4
    Homologene
    FAMILY penta-EF hand (PEF) family of calcium binding proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • co-localized with ryanodine receptors at the Z-lines
  • stomatin, sorcin, and synexin were shown to locate mainly outside induced GM1 (ganglioside M1) patches in the human erythrocyte membrane
    • basic FUNCTION
  • potential regulator of interchannel communication during excitation-contraction coupling in heart and skeletal muscle
  • Ca2+ binding protein implicated in the regulation of intracellular Ca2+ cycling and cardiac excitation-contraction coupling
  • important gene associated with the development of multidrug-resistance in leukemia cells
  • intramitochondrial Sorcin plays a role in TRAP1 cytoprotection
  • TRAP1 and Sorcin are both implicated in multidrug resistance and are coupregulated in human colorectal carcinomas
  • ANXA7 and sorcin are cytosolic proteins that are actors in vesicular trafficking and exocytosis
  • enhances the accumulation of Ca(2+) in the endoplasmic reticulum (ER), preventing ER stress
  • regulates intracellular calcium homeostasis and plays a role in the induction of drug resistance in cancers
  • retains MLXIPL in the cytosol at low glucose concentrations and may act as a Ca(2+) sensor for glucose-induced nuclear translocation and the activation of MLXIPL-dependent genes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • ryamodine receptor for modulating intracellular calcium channel
  • interacts with intracellular target proteins after Ca(2+) binding
  • sorcin binding to the SLC8A1 calcium binding domains (CBD1)
  • Sorcin is a new TRAP1 interactor
  • in the excitable pancreatic beta-cell, MLXIPL interacts with sorcin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in multidrug resistant lines cells
    tumoral     --over  
    resulted in increased drug resistance, to a variety of chemotherapeutic agents, including doxorubicin, etoposide
    constitutional germinal mutation      
    in hypertrophic cardiomyopathy (HCM)
    tumoral     --over  
    Colorectal cancer cells overexpress sorcin as an adaptive mechanism to prevent ER stress and escape apoptosis triggered by chemotherapeutic agents
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice overexpressing L112-sorcin in the heart, have mildly dilated heart but ventricular function was preserved and systemic blood pressure was normal. Sorcin (F112L) myocytes were smaller than control cells and displayed complex alterations in Ca2+ regulation and contractility