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FLASH GENE
Symbol SRI contributors: mct/pgu - updated : 02-05-2012
HGNC name sorcin
HGNC id 11292
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in multidrug resistant lines cells
tumoral     --over  
resulted in increased drug resistance, to a variety of chemotherapeutic agents, including doxorubicin, etoposide
constitutional germinal mutation      
in hypertrophic cardiomyopathy (HCM)
tumoral     --over  
Colorectal cancer cells overexpress sorcin as an adaptive mechanism to prevent ER stress and escape apoptosis triggered by chemotherapeutic agents
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
mice overexpressing L112-sorcin in the heart, have mildly dilated heart but ventricular function was preserved and systemic blood pressure was normal. Sorcin (F112L) myocytes were smaller than control cells and displayed complex alterations in Ca2+ regulation and contractility