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FLASH GENE

Symbol

SRI

contributors: mct/pgu - updated : 02-05-2012

HGNC name	sorcin
HGNC id	11292

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in multidrug resistant lines cells tumoral     --over   resulted in increased drug resistance, to a variety of chemotherapeutic agents, including doxorubicin, etoposide constitutional germinal mutation       in hypertrophic cardiomyopathy (HCM) tumoral     --over   Colorectal cancer cells overexpress sorcin as an adaptive mechanism to prevent ER stress and escape apoptosis triggered by chemotherapeutic agents

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice overexpressing L112-sorcin in the heart, have mildly dilated heart but ventricular function was preserved and systemic blood pressure was normal. Sorcin (F112L) myocytes were smaller than control cells and displayed complex alterations in Ca2+ regulation and contractility