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FLASH GENE
Symbol SRFBP1 contributors: mct/npt - updated : 22-02-2010
HGNC name serum response factor binding protein 1
HGNC id 26333
Location 5q23.1      Physical location : 121.297.655 - 121.364.295
Synonym name SRF-dependent transcription regulation associated protein
Synonym symbol(s) FLJ25286, P49, STRAP, p49/STRAP
DNA
TYPE functioning gene
STRUCTURE 66.64 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2836 - 429 - Lisinski (2006)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Respiratoryrespiratory tracttrachea  highly
 respiratory tractlarynx  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, ageing
Text fetal and senescent heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four classic nuclear localization sequence motifs (Zhang 2008)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text present predominantly in the nucleus (Zhang 2008)
    basic FUNCTION
  • possible role in biosynthesis and/or processing of GLUT4 in adipose cells
  • may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span
  • cofactor of serum response factor that contributes to the regulation of SRF target genes in the heart (Zhang 2008)
  • plays a role in the regulation of intracellular processes such as cardiac cellular metabolism, gene expression, and possibly aging (Zhang 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with an acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4
  • SRF cofactor (expression of SRFBP1 affected the promoter activity of SRF target genes in a non-uniform manner)
  • interacting with NDUFAB1 (interacted and co-localized with each other in the cell) (Zhang 2008)
  • co-chaperone of Hsp70 (Lin 2009)
  • interacted with the beta-sandwich subdomain of HPA8 (Lin 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS