Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SRFBP1 contributors: mct/npt - updated : 02-11-2022
HGNC name serum response factor binding protein 1
HGNC id 26333
Location 5q23.1      Physical location : 121.297.655 - 121.364.295
Synonym name
  • SRF-dependent transcription regulation associated protein
  • BUD22 homolog
  • Synonym symbol(s) FLJ25286, P49, STRAP, p49/STRAP, BUD22, Rlb1
    DNA
    TYPE functioning gene
    STRUCTURE 66.64 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2836 - 429 - 2016 27337995
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Respiratoryrespiratory tracttrachea  highly
     respiratory tractlarynx  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, ageing
    Text fetal and senescent heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four classic nuclear localization sequence motifs (Zhang 2008)
  • a SRF binding domain
  • a BUD22 domain (which modulates cellular growth rate and cell size)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    text present predominantly in the nucleus (Zhang 2008)
    basic FUNCTION
  • possible role in biosynthesis and/or processing of GLUT4 in adipose cells
  • may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span
  • cofactor of serum response factor that contributes to the regulation of SRF target genes in the heart (Zhang 2008)
  • plays a role in the regulation of intracellular processes such as cardiac cellular metabolism, gene expression, and possibly aging (Zhang 2008)
  • likely regulates cell size and morphology through SRF target genes
  • SRFBP1 is an HCV-specific, pan-genotypic host entry factor
  • is a transcriptional regulator that has been implicated in cardiac aging
  • may likely play a role in glucose-deprivation associated cytoskeletal changes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with an acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4
  • SRF cofactor (expression of SRFBP1 affected the promoter activity of SRF target genes in a non-uniform manner)
  • interacting with NDUFAB1 (interacted and co-localized with each other in the cell) (Zhang 2008)
  • co-chaperone of Hsp70 (Lin 2009)
  • interacted with the beta-sandwich subdomain of HPA8 (Lin 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS