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FLASH GENE
Symbol SRFBP1 contributors: mct/npt - updated : 02-11-2022
HGNC name serum response factor binding protein 1
HGNC id 26333
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four classic nuclear localization sequence motifs (Zhang 2008)
  • a SRF binding domain
  • a BUD22 domain (which modulates cellular growth rate and cell size)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    text present predominantly in the nucleus (Zhang 2008)
    basic FUNCTION
  • possible role in biosynthesis and/or processing of GLUT4 in adipose cells
  • may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span
  • cofactor of serum response factor that contributes to the regulation of SRF target genes in the heart (Zhang 2008)
  • plays a role in the regulation of intracellular processes such as cardiac cellular metabolism, gene expression, and possibly aging (Zhang 2008)
  • likely regulates cell size and morphology through SRF target genes
  • SRFBP1 is an HCV-specific, pan-genotypic host entry factor
  • is a transcriptional regulator that has been implicated in cardiac aging
  • may likely play a role in glucose-deprivation associated cytoskeletal changes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with an acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4
  • SRF cofactor (expression of SRFBP1 affected the promoter activity of SRF target genes in a non-uniform manner)
  • interacting with NDUFAB1 (interacted and co-localized with each other in the cell) (Zhang 2008)
  • co-chaperone of Hsp70 (Lin 2009)
  • interacted with the beta-sandwich subdomain of HPA8 (Lin 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS