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FLASH GENE
Symbol SPRED2 contributors: mct - updated : 11-05-2015
HGNC name sprouty-related, EVH1 domain containing 2
HGNC id 17722
Location 2p14      Physical location : 65.537.985 - 65.659.656
Synonym name
  • sprouty protein with EVH-1 domain 2, related sequence
  • sprouty-related protein with EVH-1 domain 2
  • Synonym symbol(s) Spred-2, FLJ21897, FLJ31917
    DNA
    TYPE functioning gene
    STRUCTURE 121.60 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    OTX1 2p13 orthodenticle homolog 1 (Drosophila) LOC51057 2p15 hypothetical protein LOC51057 MDH1 2p16 malate dehydrogenase 1, NAD (soluble) LOC388955 2 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) LOC391377 2 similar to ribosomal protein S4 LOC391378 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) UGP2 2p14-p13 UDP-glucose pyrophosphorylase 2 VPS54 2p13-p14 vacuolar protein sorting 54 (yeast) PELI1 2p13.3 pellino homolog 1 (Drosophila) LOC130773 2p15 similar to 60S ribosomal protein L23a HSPC159 2p15 HSPC159 protein FLJ20080 2p15 hypothetical protein FLJ20080 TRIP-Br2 2p15 transcriptional regulator interacting with the PHS-bromodomain 2 SLC1A4 2p13.3 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 LOC200731 2p14 hypothetical LOC200731 KIAA0582 2p14 hypothetical LOC200731 RAB1A 2p14 RAB1A, member RAS oncogene family LOC150984 2p14 similar to voltage-dependent anion channel isoform 2 ACTR2 2p14 ARP2 actin-related protein 2 homolog (yeast) SPRED2 2p14 sprouty-related, EVH1 domain containing 2 LOC388956 2 LOC388956 LOC391379 2 similar to DnaJ homolog subfamily B member 12 LOC391380 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MEIS1 2p14-p13 Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) LOC391381 2 similar to DNA cytosine methyltransferase 3 alpha isoform a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2 ETAA16 2p13-p15 ETAA16 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4457 47.6 418 - 2004 15184877
    6 - 4104 47 415 - 2004 15184877
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
     stomach   highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    Lymhoid/Immunelymphocyte
    Lymphoid/ImmuneB cell
    Reproductiveepithelial cell
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    physiological period fetal
    Text all fetal tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cys-rich domain responsible for the localization of the protein to the membrane ruffles
  • one EVH1 domain (enabled/vasodilatator-stimulated phosphoprotein homology 1)
  • conjugated Other
    HOMOLOGY
    Homologene
    FAMILY sprouty family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text in the cytoplasm in unstimulated cells but translocated to the membrane ruffles in cells stimulated with EGF(epidermal growth factor)
    basic FUNCTION
  • may be functioning as an antagonist of fibroblast growth factor (FGF) pathways and may be negatively modulating respiratory organogenesis
  • may be having an important function in chondrocytes and bone development
  • modulate Ras-Raf interaction and MAP kinase signalling
  • key regulator of RhoA-mediated cell motility and signal transduction
  • SPRED1, SPRED2, SPRED3 modulate growth factor receptor signaling by inhibiting the RAS-MAPK cascade
  • both SPRED1 and SPRED2 inhibit the ability of DYRK1A to phosphorylate its substrates
  • likely involved in the regulation of dynamic developmental processes
  • negative regulator of the hypothalamic-pituitary-adrenal axis
  • SPRED1, SPRED2 negatively regulates lens growth by modulating epithelial cell proliferation and fiber differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPRED2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling
  • direct and endogenous interaction of SPRED1 and SPRED2 with the novel kinase, DYRK1A (bind to a similar domain on DYRK1A as Tau, and possibly other substrates, and the hierarchy of binding will depend on the concentration of the competing proteins and the relative affinity for the DYRK1A-binding site)
  • cell & other
    REGULATION
    repressed by role for SPRED2 tyrosine phosphorylation and ubiquitination in controlling SPRED2 expression levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of Spred-2 inhibits bone growth by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway
  • Spred2(-/-) mice exhibit dwarfism and increase of early haematopoiesis