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FLASH GENE
Symbol SPRED2 contributors: mct - updated : 24-11-2021
HGNC name sprouty-related, EVH1 domain containing 2
HGNC id 17722
ASSOCIATED DISORDERS
corresponding disease(s) NNL4
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
impairs autophagy, leading to cardiac dysfunction and life-threatening arrhythmias
Susceptibility to rheumatoid arthritis (RA)
Variant & Polymorphism other
  • SPRED2 is an RA-susceptibility gene
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    SPRED2 may be a new therapeutic target for the treatment of ulcerative colitis (UC)
    ANIMAL & CELL MODELS
  • loss of Spred-2 inhibits bone growth by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway
  • Spred2(-/-) mice exhibit dwarfism and increase of early haematopoiesis
  • Spred2-/-mice were reported to have a markedly reduced growth and shorter long bones,54 cardiac fibrosis and arrhythmias, and a shortened lifespan