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FLASH GENE
Symbol SPRED1 contributors: npt/pgu - updated : 09-11-2018
HGNC name sprouty-related, EVH1 domain containing 1
HGNC id 20249
Corresponding disease
NFLS neurofibromatosis 1-like syndrome
Location 15q14      Physical location : 38.545.051 - 38.649.449
Synonym name
  • EVH1/Sprouty domain containing protein
  • suppressor of Ras/MAPK activation
  • Synonym symbol(s) FLJ33903, Spred-1, NFLS
    DNA
    TYPE functioning gene
    STRUCTURE 121.67 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HH114 15q13.3 hypothetical protein HH114 LOC390575 15 similar to casein kinase 1, alpha 1 MEIS2 15q14 Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) LOC145846 15q13.3 hypothetical LOC145846 LOC390576 15 similar to ribosomal protein S15 MGC35118 15q13.3 hypothetical protein MGC35118 SPRED1 15q13.3 sprouty-related, EVH1 domain containing 1 FLJ38426 15q13.3 hypothetical protein FLJ38426 RASGRP1 15q15 RAS guanyl releasing protein 1 (calcium and DAG-regulated) THBS1 15q15 thrombospondin 1 FLJ35989 15q14 hypothetical protein FLJ35989 GPR 15q14 putative G protein coupled receptor LOC388113 15 hypothetical gene supported by BC035481 MGC10997 15q13-q14 pseudogene MGC10997 SRP14 15q15.1-q21.1 signal recognition particle 14kDa (homologous Alu RNA binding protein) BMF 15q14 Bcl2 modifying factor BUB1B 15q15 BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) PAK6 15q14 p21(CDKN1A)-activated kinase 6 LOC390577 15 similar to KIAA1728 protein PLCB2 15q15 phospholipase C, beta 2 LOC390578 15 similar to BLOCK 23 LOC388114 15 LOC388114 LOC388115 15 similar to RIKEN cDNA 2600011L02
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 7255 - 444 - 2001 11493923
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text all fetal tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cys-rich domain responsible for the localization of the protein to the membrane ruffles, highly homolog to the CRD of the Sprouty family of proteins
  • one EVH1 domain (enabled/vasodilatator-stimulated phosphoprotein homology 1)
  • a Sprouty domain not required to block MAPK (mitogen-activated protein kinase) activation
  • a cysteine-rich (CR) domain at the C-terminus, which is thought to be palmitoylated like CAV1 and necessary for membrane anchoring
  • HOMOLOGY
    Homologene
    FAMILY
  • sprouty family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text in the cytoplasm in unstimulated cells but translocated to the membrane ruffles in cells stimulated with egf (epidermal growth factor)
    basic FUNCTION
  • may be functioning as an antagonist of fibroblast growth factor (FGF) pathways and may be negatively modulating respiratory organogenesis
  • key regulator of RhoA-mediated cell motility and signal transduction
  • inhibiting ERK activation in collaboration with CAV1
  • modulate Ras-Raf interaction and MAP kinase signalling
  • SPRED1, SPRED2, SPRED3 modulate growth factor receptor signaling by inhibiting the RAS-MAPK cascade
  • the three-way interaction between SPRED1, TAOK1, and TESK1 represents a pathway that links regulation of both the microtubule- and F-actin cytoskeleton (Johne 2008)
  • membrane associated negative regulators of growth factor induced extracellular signal regulated kinases (ERK) activation
  • negatively regulates haematopoiesis by suppressing stem cell factor (SCF) and interleukin 3 (IL3) induced ERK activation
  • inhibit the Ras/ERK pathway downstream of RAS
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TAOK1 (two new interaction partners of TAOK1, SPRED1 and the testis-specific protein kinase (TESK1)
  • direct and endogenous interaction of SPRED1 and SPRED2 with the novel kinase DYRK1A (bind to a similar domain on DYRK1A as Tau, and possibly other substrates, and the hierarchy of binding will depend on the concentration of the competing proteins and the relative affinity for the DYRK1A-binding site)
  • both SPRED1 and SPRED2 inhibit the ability of DYRK1A to phosphorylate its substrates
  • GPM6A, and the Sprouty domain-containing proteins SPRED1 and SPRED3, are indeed palmitoylated by ZDHHC17
  • cell & other
    REGULATION
    induced by FGF signaling.
    ASSOCIATED DISORDERS
    corresponding disease(s) NFLS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma is one of the causes of the acquisition of malignant features
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS