basic FUNCTION
| may be functioning as an antagonist of fibroblast growth factor (FGF) pathways and may be negatively modulating respiratory organogenesis |
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key regulator of RhoA-mediated cell motility and signal transduction |
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inhibiting ERK activation in collaboration with CAV1 |
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modulate Ras-Raf interaction and MAP kinase signalling |
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SPRED1, SPRED2, SPRED3 modulate growth factor receptor signaling by inhibiting the RAS-MAPK cascade |
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the three-way interaction between SPRED1, TAOK1, and TESK1 represents a pathway that links regulation of both the microtubule- and F-actin cytoskeleton (Johne 2008) |
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membrane associated negative regulators of growth factor induced extracellular signal regulated kinases (ERK) activation |
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negatively regulates haematopoiesis by suppressing stem cell factor (SCF) and interleukin 3 (IL3) induced ERK activation |
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inhibit the Ras/ERK pathway downstream of RAS |
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diet-induced stress disrupts fine-tuning of SPRED1-mediated signals to govern hematopoietic stem cell homeostasis |
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SPRED1, SPRED2 negatively regulates lens growth by modulating epithelial cell proliferation and fiber differentiation |
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SPRED1, SPRED2 are required for the continuous embryonic growth and differentiation of the lens |