basic FUNCTION
| catalyzing the final step of tetrahydrobiopterin (BH4) synthesis, cofactor for aromatic aminoacid hydroxylase and nitric oxid synthase |
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important role of endothelial SPR in modulating tetrahydrobiopterin (H(4)B) and nitric oxide (NO(*) bioavailability |
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SPR is a key enzyme mediating chemical redox cycling suggests that it may be important in generating cytotoxic reactive oxygen species in the lung |
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mediates chemical redox cycling in lung epithelial cells |
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mediates chemical redox cycling, catalyzing one-electron reduction of redox-active chemicals, including quinones |
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GCH1, SPR and their downstream metabolite BH4 are critical regulators of T cell biology that can be readily manipulated to either block autoimmunity or enhance anticancer immunity |
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catalyzes both the reversible reduction of sepiapterin to dihydrobiopterin (BH2) and 6-pyruvoyl-tetrahydrobiopterin to BH4 within the BH4 pathway |