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FLASH GENE

Symbol

SPR

contributors: mct - updated : 12-11-2019

HGNC name	sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
HGNC id	11257

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SPRD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   is significantly correlated to unfavorable Neuroblastoma (NB) characteristics like high age at diagnosis

Susceptibility

Variant & Polymorphism

Candidate gene	for PARK3
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   tranilast can act as a potent SPR inhibitor and therefore is a valid candidate for drug repurposing in the treatment of chronic pain immunology autoimmune articular SPR inhibition reduces pain associated with joint inflammation, showing potential utility as an analgesic strategy for inflammatory joint pain

ANIMAL & CELL MODELS