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FLASH GENE
Symbol SPECC1L contributors: mct - updated : 26-10-2011
HGNC name sperm antigen with calponin homology and coiled-coil domains 1-like
HGNC id 29022
Corresponding disease
OBLFC1 oblique facial clefting 1
Location 22q11.23      Physical location : -
Genatlas name
  • cytospin A
  • Spectrin-1-like
    • Synonym name
  • cDNA sequence,expressed in brain,>100kDa,related to CENPE
  • cytospin-A
  • renal carcinoma antigen NY-REN-22
  • Mps1 interacting protein-1
    • Synonym symbol(s) KIAA0376, CYTSA, OBLFC1, MIP1
    DNA
    TYPE functioning gene
    STRUCTURE 146.92 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 6795 123 1117 - 2011 21325884
    16 - 6691 123 1117 - 2011 21325884
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal (AAs 1–351)
  • central coiled-coil (AAs 351–851), specifically bound by TTK
  • C-terminal (AAs 851–1,117) segments, with calponin homology domain (CH), important for the association with actin filaments
    • either through direct binding of SPECC1L to actin or via association
    with other actin binding proteins
    HOMOLOGY
    intraspecies homolog to CENPE
    Homologene
    FAMILY
  • cytospin-A family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • localizes to a part of the actin filament network during interphase
  • localized to the mitotic spindle during mitosis and to the cytokinetic furrow at an early stage and remained there throughout cell division suggesting a role for the protein in cytokinesis
    • basic FUNCTION
  • required for proper actin organization during
    • mitosis
  • functions to position and stabilize the mitotic
    • spindle
  • its function may be independent of anillin,
    • but require interaction with other cytokinesis components such as actin, myosin or the ezrin, radixin, moesin (ERM) protein family
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TTK
  • interaction with anillin could explain the
    • complexity of effects we observed with SPECC1L reduction
    in cells
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OBLFC1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS